Heart Enzymes- normal and abnormal markers

Question 1

what cardiac enzyme markers are important to consider?

Answer 1

CK-MB
cardiac troponin
CK
SGOT/AST
LDH

Question 2

CK-MB (creatine kinase myocardial band) clinical significance

Answer 2

marker specific to cardiac muscle
elevated in acute MI, re-infarction and myocarditis

Question 3

what enzyme marker is specific to cardiac muscle and elevated in acute MI, re-infarction and myocarditis?

Answer 3

CK-MB

Question 4

what is the normal range of CK-MB?

Answer 4

CK-MB < 5 ng/ml
CK-MB < 3-5% CK (total)

Question 5

CK-MB becomes elevated/rises after/appears __-__ hrs in the case of acute MI, re-infarction or myocarditis?

Answer 5

3-6 hrs

Question 6

CK-MB peaks within __-__ hrs in the case of acute MI, re-infarction or myocarditis?

Answer 6

12-24 hrs

Question 7

CK-MB returns to normal within __-__ days in the case of acute MI, re-infarction or myocarditis?

Answer 7

2-3 days

Question 8

cardiac troponin (I or T) clinical significance?

Answer 8

most specific and sensitive marker for myocardial injury
gold standard for MI especially if seen w/in 6-24 hrs of chest pain onset
elevation indicates MI

Question 9

what cardiac enzyme marker is the most specific and sensitive marker for myocardial injury?

Answer 9

cardiac troponin

Question 10

what cardiac enzyme marker is the gold standard for MI especially if seen within 6-24 hours of chest pain onset?

Answer 10

cardiac troponin

Question 11

what cardiac enzyme marker is elevated in MI?

Answer 11

cardiac troponin

Question 12

cardiac troponin is the gold standard for MI, especially if seen within __-__ hrs of chest pain onset

Answer 12

6-24

Question 13

what is the normal range of cardiac troponin I?

Answer 13

troponin I < 0.04 ng/ml

Question 14

cardiac troponin becomes elevated/rises after/appears __-__ hrs in the case of MI?

Answer 14

3-6 hrs

Question 15

cardiac troponin peaks within __-__ hrs in the case of MI?

Answer 15

12-24 hrs

Question 16

cardiac troponin returns to normal within __-__ hrs in the case of MI?

Answer 16

7-10 days

Question 17

why is CK-MB a better marker for detecting re-infarction when comparing it to cardiac troponin?

Answer 17

it returns to normal faster (2-3 days) than cardiac troponin (7-10 days)

Question 18

CK (creatine kinase total) clinical significance?

Answer 18

not cardiac specific- indicates cardiac or skeletal muscle damage

Question 19

what cardiac enzyme marker is not cardiac specific, with elevated levels indicating cardiac or skeletal muscle damage?

Answer 19

CK (total)

Question 20

what is the normal range of CK (total) in males and females?

Answer 20

males: 38-174 U/L
females: 26-140 U/L

Question 21

CK (total) appears/becomes elevated/ rises after __-__ hrs in the case of cardiac or skeletal muscle damage

Answer 21

3-6 hrs

Question 22

CK (total) peaks after __-__ hrs in the case of cardiac or skeletal muscle damage

Answer 22

12-24 hrs

Question 23

CK (total) returns to normal after __-__ days in the case of cardiac or skeletal muscle damage

Answer 23

2-3 days

Question 24

serum glutamic-oxaloacetic transaminase/aspartate aminotransferase (SGOT/AST) clinical significance?

Answer 24

present in liver, cardiac and skeletal muscle-elevated in MI and hepatitis

Question 25

what cardiac enzyme marker is present in liver, cardiac and skeletal muscle and is elevated in the case of MI and hepatitis?

Answer 25

SGOT/AST

Question 26

what is the normal range of SGOT/AST?

Answer 26

10-40 U/L

Question 27

SGOT/AST appears/becomes elevated/rises after __-__ hrs in the case of MI and hepatitis?

Answer 27

6-12 hrs

Question 28

SGOT/AST peaks after __-__ hrs in the case of MI and hepatitis?

Answer 28

24-48 hrs

Question 29

SGOT/AST returns to normal after __-__ days in the case of MI and hepatitis?

Answer 29

3-5 days

Question 30

lactate dehydrogenase (LDH) clinical significance?

Answer 30

not cardiac specific- also found in the liver, kidneys and RBCs LDH1/LDH2 flip can indicate MI

Question 31

what cardiac enzyme marker is not cardiac specific and is also found in the liver, kidneys and RBCs?

Answer 31

LDH

Question 32

an LDH1/LDH2 flip can indicate what type of cardiac injury?

Answer 32

MI

Question 33

what is the normal range of LDH?

Answer 33

140-280 U/L

Question 34

an __/__ flip can indicate MI

Answer 34

LDH1/LDH2

Question 35

LDH appears/becomes elevated/rises after __-__ hrs in the case LDH1/LDH2 flip indicating MI?

Answer 35

12-24 hrs

Question 36

LDH peaks after __-__ hrs in the case LDH1/LDH2 flip indicating MI?

Answer 36

2-3 days

Question 37

LDH returns to normal after __-__ hrs in the case LDH1/LDH2 flip indicating MI?

Answer 37

7-10 days