helper T cells and how they work Flashcards
two sub classes of helper T cells
Th1 and Th2
Th1 recognizes what?
ALL viral, cancer
Th2 recognizes what?
ALL bacterial
Th1 talks to…?
cytotoxic T cell
Th2 talks to…?
B Cells
Th1 primary target
intracellular pathogens
Th2 primary target
extracellular pathogens
Th1 cytokine promoting differentiation by APC
IL-1, IL-2 and others
Th2 cytokine promoting differentiation by APC
IL-1, IL-2 and others
Th1 cytokine secreted?
IL-2, interferon gamma and others
Th2 cytokine secreted?
IL-4, IL-5, and IL-6
Th1 cells activated?
macrophages, cytotoxic T cells (T-T cooperation)
Th2 cells activated?
B cells into plasma cells (T-B cooperation)
Th1 process mediated?
cellular immunity
Th2 process mediated?
humoral immunity
helper T cell (T4) target?
cytotoxic T cells
B cells
NK cells & macrophages
cytotoxic T cell target?
cells with specific antigen bound to class I MHC
B cell (10-20% of lymphocytes)
plasma cells release antibodies
helper T cell (T4) unique
CD4 protein in membrane binds with MHC class II activated cells release: interferon gamma IL-2 IL-4 IL-5
cytotoxic T cell unique
CD8 protein in membrane binds to MHC class I produces perforins and releases some stuff
B cell unique
immunoglobulin production receptors and production of
IL-1
TNF gamma
MHC class II protein (APC)
helper T cell receptors
IL-1
TNF-gamma
IL-6
IL-2+
cytotoxic T cell receptors
IL-2+ interferon gamma antigen bound to MHC class I protein
B cell receptors
IL-2
IL-4
IL-5
antigen bound to MHC class II
