innate vs. adaptive Flashcards
cells involved - innate
leukocytes
cells involved - adaptive
lymphocytes
site of action - innate
local. confined
site of action - adaptive
global, spreading
target - innate
non-specific
target - adaptive
specific epitope
timing innate
early (hrs) “first responder”
timing adaptive
late (days) “last resort”
leukocytes
neutrophils, basophils, eosinophils, monocytes
macrophages, dendritic and mast cells
lymphocytes
B cells, cytotoxic T, helper T and NK cells plasma cells (differentiated B cells)
macrophage origin
monocytes from bone marrow
NK cell origin
bone marrow
mast cell origin
unique bone marrow cells
macrophage location
outside blood vessels (skin, resp, GI GU tract)
NK cell location
blood, extracellular space
mast cell location
outside blood vessels in connective tissue
macrophage target
non-specific response; phagocytosis; cytokines (inflammation)
NK cell target
virus infected or cancer cells
or
antibody bound foreign cells
mast cell target
local inflammation to increase blood supply
macrophage unique
phagocytosis of bacteria with C3b opsonin
MHC Class II protein (APC)
CD4 protein
CCR5 protein
NK cell unique
unk surface protein to ID virus infected or cancer cells
release interferon gamma
mast cell unique
large number of vesicles secreting paracrine agents
histamine+chemokines involved in inflammation
macrophage receptors
IL2 + interferon gamma C3b (opsonin) Fc receptor for antibody TLR for carbs
NK cell receptors
IL2 +
interferon gamma
autoreceptors
Fc receptor for antibody
