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Hemato Flashcards

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1
Q

t (8;14) cmyc

A

burkitt cielo estrellado

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2
Q

t (11;14) bcl 1

A

L Manto (una persona debajo manta)

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3
Q

t (9;22)

A

LMC BCR/ABL cromosoma phidadlephia (en 5% ph negativo) buen pronostico
LLA M3: mal pronostico

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4
Q

t (14, 18)

A

Folicular

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5
Q

Pancitopenia sin esplenomegalia

A
  • Anemia aplásica

- SMD (menos Sme 5q: trombocitosis)

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6
Q

Aspirado seco

A
  • Aplasia medular (grasa)
  • Mielofibrosis
  • Tricoleucemia
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7
Q

Causa mas frecuente macrocitosis

A

Alcohol

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8
Q

No Adenopatias

A

Mieloma!

Tricoleucemia

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9
Q

Pancitopenia MAS esplenomegalia

A
  1. Mielofibrosis
  2. Tricoleucemia
  3. HPN
  4. LNH
  5. Leishmania
  6. Gaucher
  7. Cirrosis más HTP
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10
Q

Anemia macro

A
  • A Megalobástica ( neutrofilos hipersegmentados)
  • SMD (neutroflipos hoposegmentados: pseudopelger
  • Aplasia
  • Hipotiroidismo
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11
Q

Unica anemia hemolitica con hiperreticulocitosis

A

HPN

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12
Q

Trombosis venosas

A

HPN
PV
Trombocitemia Esencial

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13
Q

FAG (fosfatasa alcalina granulocitica) disminuida

A

HPN, LMC y SMD

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14
Q

FAG aumentada

A

PV

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15
Q

4 enfermedades prurito

A

PV
LHodking (EN)
Micosis fungoide
Mastocitosis sistémica

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16
Q

Sombras Gumbrecht

A

LLC

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17
Q

Ibrutinib

A

LLC si delecc17 y recaida Linfoma Manto

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18
Q

Brentuximab

A

Anti CD30 para LH Refractario

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19
Q

Decitabina

A

LAM > 65años no candidatos QT

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20
Q

5-Azacitidina

A

SMD con al estado general

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21
Q

Ttmo PTI

A

1º linea: Corticoides +/- gammaglobulina
2ºLinea: Esplenectomia o ANALOGOS DE LA TROMBOPOYETINA (MISMO nivel de evidencia!!)
Transfusiones NO contraindicadas pero poco efectivas

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22
Q

Tto PTT

A

Plasmaféresis y corticoides

CONTRAINDICADO TRAnSFUSIONES

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23
Q

Sintrom

A

aumenta TP (via corta. inhibe al 7) pero si esta muy pasado puede aumentar TTPA

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24
Q

Control HBPM excepciones

A

NO! solo antiXa en embarazadas obesos morbidos y IRC

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25
Sintrom y cirugia vital <6h
Complejo protrombínico: concentrado de protrombina y vitK
26
Efectos adversos NACO
Hemorragia.
27
Unico NACO inhibidor
DA-BIgatran: iDA-rozumab
28
BCR-ABL t (9;22)
LMC: buen pronostico o LAL: MAL PRONOSTICO
29
Eculizumab
HPN
30
aumento CCMH
Esferocitosis hereditaria
31
ID HUMORAL
LLc y MM
32
ID celular
LH y tricoleucemia
33
Hemofilia adquirida
aumento TP que no corrige con plasma- Mas frecuente ac anti8
34
No trata asintomaticos
MM, LLC, Paget, Sarcoidosis, Hiperuricemia
35
Dacriocito
mieloptisis
36
Reaccion leucoeritroblastica
mieloptisis
37
Tratamieto Aplasia medular
<45a ALOTPH | >45a ATG+Ciclosporina+Corticoides
38
A ferropenica
1er dato: disminucion ferritina 3-6d Aumento reticulocitos mantener FE 3-6m hasta restaurar FERRITINa no hasta quitar anemia!
39
Causa mas frecuente A. megaloblastica
Deficit Ac folico (deposito 3-4m) aumento HOMOCiSTEINA Ac menilmandolico NORMAL
40
Deficit B12
``` Menos frecuente (depositos 3-6años) Sintomas neurologicos +/- anemia: compiten!! puede haber clinica SNC sin anemia ```
41
Ttmo A. megaloblastica x deficit B12
B12 im + Folico!
42
Anemia perniciosa
Preneoplasica AC mas sensible: anticelparietal | mas EspeciFIco antiFI
43
A Hemolitica AC Calientes
Ig G (guarrillos), Extravasculares, LLC y LES
44
A Hemolitica AC Frios
Ig M (modositos en casa) Intravasculares, VEB, mycoplasma, Waldestrom
45
HPN
Hemolisis INTRAVASCULAR ADQUIRIDA. Deficit CD55 y 59: activacion complemetnp Trombopenia mas TROMBOSIS (Budd Chiari) Eculizumab
46
Bastones Auer
LAM
47
Sme 5q
SMD mujeres con trombocitosis: ttmo LENALIDOMIDA
48
Anemia macrocitica refractaria tto en mayor
SMD. NO DAR FE!
49
Estadiaje BINET y RAI
LLC (CD 5+, 23+)
50
Sme RITCHER
LLC que evoluciona a LDCG
51
Esplenomegalia+ legionallea+ PAN
Tricoleucemia: Slinfoprol B. NO ADENOPATIAS | CD103+
52
LNH mas frecuente occidente
LBCG (bcl 6)
53
LNH bajo grado mas frecuente
L. Folicular (14,18) bcl2
54
Ann Arbor
LH
55
Cel Red Stenberg
CD 15+ 30+
56
Sme Zieve
Hiperlipidemia Hemolisis y Hepatopatia
57
pancitopenia, “orinas oscuras” y trombosis venosas
HPN
58
CAusas anemia macro
hipotiroidismo, aplasia medular, smes mielodisplásico y a.megaloblastica
59
Primera causa muerte MM
Infecciones: ID Humoral por Ac anomalos 2º insuficiencia renal por la excreción de cadenas ligeras (proteinuria de Bence-Jones) y la hipercalcemia Peor pronostico: ausencia respuesta citostaticos
60
anemia micro
ferropenica, intox plomo (sideroblastica), sideroblastica, talasemia ( nº hematies N o aumentado)
61
leucemia aguda + CID
Leucemia M3 promielocitica: ATRA
62
anciano pancitopenia + macrocitosis
SMD (menos 5q) NO dar Fe de ttmo!!!
63
1º causa mortalidad LLC
infecciones: hipogammaglobulineamia
64
LLC asint ttmo
Expectante
65
neutropenia febril+fiebre+dolor fosa iliaca derecha
Tiflitis. Causa: PSEUDOMONAS A
66
peor pronostico LLC
trombopenia (rai y binet)
67
anemia + trombocitosis
ferrropenica. Trombocitosis reactiva x intento de compensacion
68
ttmo MM <70A
QT altas dosis + AUTOTPH
69
células T pleomórficas CD4 positivas+ lesiones liticas en linfomaL
LT adulto: virus HTLV1

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