Hemato/blood Physio Pt 2/2 (Hemostasis and Anti-coag)

Question 1

What are blood clots consist of?

Question 2

Explain the process of primary hemostasis.

Answer 2

Note: primary hemostasis = platelet plug formation -> 3 main steps!

Question 3

Does thrombin play a role in platelet adhesion, activation or aggregation?

Question 4

Which phase: A, A, or A, does aspirin disturb (in pri hemostasis)?

Question 5

Explain the process of secondary hemostasis. (rmb to incl the requirements)!

Answer 5

Note: primary hemostasis = blood clot formation

Question 6

Which clotting factors need which Vit for production?

Question 7

Where are clotting factors made, and what (material) are they?

Any exceptions?

Answer 7

Liver; plasma proteins

except:
Ca2+, ion from diet mostly
Tissue factor, from damaged endothelial cells

Question 8

Why is thrombin said to be part of positive feedback loop in coagulation cascade?

Question 9

What factors do:
(i) thrombin activate
(ii) anti-thrombin deactivate?

Question 10

What are the 3 parts to anticoagulation? Explain each part.

Hint:
1. NP
2. ATA
3. tPA+fibrin

Answer 10

1. NP [platelet plug prevention]
2. ATA [blood clot prev]
3. tPA+fibrin [blood clot removal]

Question 11

What does serum D-dimer levels (high) indicate

Question 12

What increases the risk of thrombosis?

Answer 12

Virchow’s Triad HE’S
- what are the sub-factors?