Hematology

Question 1

B-thalassemia major also known as………….

Answer 1

Cooley’s anemia

Question 2

Deferoxamine side effects (DFO)

Answer 2

Convulsions
Coma
Cataracts
Retinal damage
Deafness
Impairment of growth
Infections by yersinia

Question 3

Deferiprone side effects

Answer 3

Agranulocytosis
Arthropathy
Possible hepatic fibrosis

Question 4

Deferaxirox side effects

Answer 4

Mainly GIT troubles and renal impairment

Question 5

Hereditary hemorrhagic telangiectasia is also called……….

Answer 5

Osler
Randu
Weber syndrome

Question 6

What may be the initial presentation in HS?

Answer 6

Aplasia due to parvovirus B19 infection (the virus attacks proerythroblasts)

Question 7

Treatment of severe HS is …..

Answer 7

Splenectomy

Question 8

b-thalassemia is mainly due to ……….. while a-thalassemia is mainly due to ……………

Answer 8

-gene mutation
-gene deletion

Question 9

Beta globin genes are located on chromosome…..

Answer 9

11

Question 10

…… is the predominant hemoglobin in B-thalassemia

Answer 10

Hemoglobin F (HbF)

Question 11

What does cause the sickle in SCD?

Answer 11

Polymerization of HbS molecules inside the red cells (polymerization results only in deoxygenation)

Question 13

What are the second generation of tyrosine kinase inhibitors (TKI) ?

Answer 13

Dasatinib
Nilotinib
Bosutinib

Question 14

……… is useful for diagnosis of different types of von willebrand disease

Answer 14

Multimer analysis