Hematology

Question 1

a HEME PREPARATION will repress

Answer 1

ALA synthase

Question 2

Deficiency of what RBC enzymes has the same PP as G6PD?

Answer 2

glutathione reductase

Question 3

Blood parameter not related to hemoglobin function

Answer 3

blood partial pressure of O2

Question 4

Methemoglobinemia presentation

Answer 4

causes a dusky discoloration of the skin, functional anemia

Question 5

absent expression of PECAM 1 gene will affect the neutrophilic function of

Answer 5

transmigration

Question 6

Deficient flow pathway in G6PD

Answer 6

G6P to 6PG

Question 7

To cause fetal hemolysis, maternal antibodies must be

Answer 7

predominantly IgM

Question 8

Baby with megaloblastic anemia and high plasma homocysteine levels. Unable to form methylcobalamin. Synthesis of what substance is ML impaired?

Answer 8

methionine

Question 9

Rx: long term anticoagulant to prevent venous thrombosis and resultant pulmonary embolism

Answer 9

warfarin

Question 10

drug of choice for acute mgmy VT or TE

Answer 10

heparin

Question 11

Patients with chronic hemolytic anemia are predisposed to

Answer 11

folic acid deficiency and macrocytic changes due to increased erythrocyte turnover

Question 12

hemloytic anemia, a hypercoagulable state, and decreased blood counts

Answer 12

PNH

Question 13

intrvascular hemolytic anemias are characterized by

Answer 13

decreased serum haptoglobin, increased Hgb, LDH, bilirubin

Question 14

Most helpful for the consideration of spherocytosis

Answer 14

Increased MCHC, because of mild dehydration of the RBC

Question 15

Spherocytosis- highest risk for developing

Answer 15

pigmented gallstones (complication of any hemolytic anemia)

Question 16

Helpful in hx for T vs B cell ALL

Answer 16

T cell ALL presents as a mediastial mass that can cause respi sx, dysphagia, or superior vena cava syndrome

Question 17

In the lungs, Hgb binds O2 and releases protons; tissues…

Answer 17

releases O2 and acquires protons

Question 18

Raltegravir

Answer 18

integrase inhibitor that disrupts the ability of HIV to integrate its genome into the host cell’s chromosomes

Question 19

NNRTI’s

Answer 19

arv drigs that do not require activation via intracellular phosphorylation.

Question 20

more common NNRTI’s

Answer 20

nevirapine, efavirenz, delaviridine

Question 21

Normal bell shaped curve: percentage within one standard deviation of the mean

Answer 21

68%

Question 22

% of obs within two SD’s of mean

Answer 22

95%

Question 23

within 3 SD’s of the mean

Answer 23

99.7%

Question 24

Increases immediately once Vit B12 is administered

Answer 24

retic count