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Flashcards in Hematology Deck (136)
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121

What is the etiology of classic vitamin k deficiency in the first week of life?

poor vitamin K intake, usually breastfed

122

What is the etiology of late vitamin k deficiency in the first eight weeks of life?

1) fat malabsorption (biliary atresia, CF, alpha 1 antitrypsin)
2) poor intake
3) antibiotics

123

What is DIC?

consumptive coagulopathy; uncontrolled activation and consumption of plt, procoagulant, anticoagulant and fibrinolytic proteins

124

What are the most frequent causes of DIC?

- sepsis
- NEC
- hypoxia/ acidosis
- liver failure

125

What is the treatment for DIC?

treat the underlying cause, transfusion support and keep up the factors

126

What is the pathology of bleeding d/t liver failure in the newborn?

1) failure of protein synthesis
2) consumption of clotting factors
3) inhibition of normal coagulation, failure to clear degradation products

127

What is the indicated treatment for bleeding d/t liver failure?

successful treatment is dependent on treatment of liver failure

128

What are the indications for a PRBC tx?

1) hypovolemia
2) anemia

129

What are the components in a PRBC tx?

RBCs + some WBCs, no immunoglobulins or clotting factors

130

What are the indications for FFP tx?

1) bleeding
2) DIC
3) vit K deficient
4) factor IX deificient

131

What are the components in FFP?

all clotting facotrs, fibrinonectin, albumin, plasma proteins

132

What are the indications for a cryo tx?

1) VIII deficiency
2) von Wildebrand

133

What are the components in cryo?

FIBRINOGEN, VIII, XIII, vWF, fibrinonectin

134

What are the indications for a plt tx?

1) thrombocytopenia
2) bleeding

135

What components are in plt tx?

platelets with some WBCs

136

What is the risk for cord injury with a velamentous cord insertion?

the umbilical cord abnormally inserts into the fetal membranes and into the placenta, leaving the vessels exposed (no Wharton's Jelly) and therefore, a great risk of rupture