Flashcards in Hematology Deck (136)
What is the etiology of classic vitamin k deficiency in the first week of life?
poor vitamin K intake, usually breastfed
What is the etiology of late vitamin k deficiency in the first eight weeks of life?
1) fat malabsorption (biliary atresia, CF, alpha 1 antitrypsin)
2) poor intake
What is DIC?
consumptive coagulopathy; uncontrolled activation and consumption of plt, procoagulant, anticoagulant and fibrinolytic proteins
What are the most frequent causes of DIC?
- hypoxia/ acidosis
- liver failure
What is the treatment for DIC?
treat the underlying cause, transfusion support and keep up the factors
What is the pathology of bleeding d/t liver failure in the newborn?
1) failure of protein synthesis
2) consumption of clotting factors
3) inhibition of normal coagulation, failure to clear degradation products
What is the indicated treatment for bleeding d/t liver failure?
successful treatment is dependent on treatment of liver failure
What are the indications for a PRBC tx?
What are the components in a PRBC tx?
RBCs + some WBCs, no immunoglobulins or clotting factors
What are the indications for FFP tx?
3) vit K deficient
4) factor IX deificient
What are the components in FFP?
all clotting facotrs, fibrinonectin, albumin, plasma proteins
What are the indications for a cryo tx?
1) VIII deficiency
2) von Wildebrand
What are the components in cryo?
FIBRINOGEN, VIII, XIII, vWF, fibrinonectin
What are the indications for a plt tx?
What components are in plt tx?
platelets with some WBCs