Hematology Correlates

Question 1

Heme precursor

Answer 1

Succinyl CoA (TCA intermediate) and Glycine (amino acid)

Question 2

Energy source of RBC

Answer 2

Anaerobic glycolysis (net of 2 ATP)

Question 3

Last stage of RBC with a nucleus

Answer 3

Orthochromic erythroblast

Question 4

Baby RBCs; increase in hemolysis

Answer 4

Reticulocytes

Question 5

Adult Hgb

Fetal Hgb

Answer 5

Adult Hgb: 2 alpha chains, 2 beta chains

Fetal Hgb: 2 aplha chains, 2 gamma chains

Question 6

Transfers iron in the blood

Stores iron in the liver

Answer 6

Transfer: transferrin
Store: ferritin

Question 7

Tissue macrophages. Bone, Liver, Skin, CNS, Lungs

Answer 7

Bone: osteoclast
Liver: Kupffer cells
Skin: histiocytes/Langerhans cells
CNS: microglia
Lungs: alveolar macrophages

Question 8

Platelet adhesion

Platelet aggregation

Answer 8

Adhesion: Glycoprotein 1b and vWF
Aggregation: Glycoprotein IIb-IIIa and fibrinogen

Question 9

Ig in primary response; largest
Ig in secondary response; smallest
Ig in secretion
Ig in allergies, parasitic

Answer 9

Ig in primary response; largest – IgM
Ig in secondary response; smallest – IgG
Ig in secretion – IgA
Ig in allergies, parasitic – IgE

Question 10

MHC I, CD8

MHC II, CD4

Answer 10

MHC I, CD8 – T Killer cells

MHC II, CD4 – T helper cells

Question 11

Patches of dilated endoplasmic reticulum that appear as sky blue cytoplasmic puddles seen in severe infection

Answer 11

Dohle bodies

Question 12

Distinctive needle-like azurophilic granules found in myeloblasts seen in AML

Answer 12

Auer rods

Question 13

Scattered macrophage with abundant wrinkles green blue cytoplasm seen in CML

Answer 13

Sea blue histiocytes

Question 14

Small lymphocytes disrupted in the process of making smears seen in CLL

Answer 14

Smudge cells

Question 15

Large cells with multiple nuclei or a single nucleus with multiple nuclear lobes in Hodgkin’s lymphoma

Answer 15

Reed Sternberg cells

Question 16

Multi lobulated nuclei seen in Adult T cell Lymphoma

Answer 16

Clover leaf or flower cells

Question 17

Destructive plasma cell tumors involving axial skeleton seen in Multiple Myeloma

Answer 17

Plasmacytoma

Question 18

Neutrophils with only two nuclear lobes seen in Myelodysplastic syndrome

Answer 18

Pseudo Pelger Huet cells

Question 19

Megakaryocytes with single nuclear lobes or multiple separate nuclei seen in MDS

Answer 19

Pawn-ball megakaryocytes

Question 20

Small yellow-brown, brown or rust colored foci in the spleen during congestion

Answer 20

Gandy- Gamma Nodules

Question 21

Most common type of Hodgkins Lymphoma
Worst and best prognosis types
Contains popcorn cells

Answer 21

Most common: Nodular sclerosis
Worst: lymphocyte- depleted
Best: lymphocyte- rich
Contains popcorn cells: lymphocyte-predominant

Question 22

Most common form of NHL

Answer 22

Diffuse large B cell lymphoma

Question 23

Translocation on chromosome 8 which present with starry sky pattern

Answer 23

Burkitt’s lymphoma

Question 24

Biopsy of tumor reveal homogenous population of small lymphocytes with no centeroblasts and proliferation centers

Answer 24

Mantle cell lymphoma

Question 25

Excess light or heavy chains along with complete immunoglobulin synthesized by neoplastic plasma cells

Answer 25

Bence Jones Proteins (Multiple Myeloma)

Question 26

Most important monoclonal gammopathy usually presenting as tumorous masses scattered throughout the skeletal system

Answer 26

Multiple Myeloma

Question 27

Small hyperchromatic RBC lacking central pallor

Answer 27

Spherocytes in Hereditary spherocytosis

Question 28

Small dark nuclear remnants present in RBC of asplenic patients

Answer 28

Howell Jolly bodies

Question 29

Membrane bound precipitates on denatures globin chains

Answer 29

Heinz body seen in G6PD deficiency

Question 30

RBCs with damaged membranes due to removal of Heinz bodies by splenic macrophages seen in G6PD deficiency

Answer 30

Bite cells

Question 31

RBCs shaped like curved blades

Answer 31

Sickle cells

Question 32

Dehydrated RBCs with bull's eye appearance seen in Sickle Cells Anemia and Thalassemia

Answer 32

Target dells (codocytes)

Question 33

Fragmented RBCs also call helmet cells if cut in half associated with RBC trauma, DIC and HUS

Answer 33

Schistocytes

Question 34

RBCs with spike associated with RBC trauma

Answer 34

Burr cells or Echinocytes

Question 35

Triad of hemolytic anemias

Answer 35

Pallor Jaundice Splenomegaly

Question 36

Intravascular vs Extravascular hemolysis

Answer 36

Extravascular hemolysis presents with splenomegaly

Question 37

Intravascular hemolysis due to increases complement-mediated RBC lysis

Answer 37

Paroxysmal Nocturnal Hemoglobinuria

Question 38

Hemolytic anemia seen in DIC, TTP-HUS, SLE and malignant hypertension

Answer 38

Microangiopathic Hemolytic anemia

Question 39

Caused by trauma to RBCs in individuals with cardiac valve prostheses

Answer 39

Microangiopathic hemolytic anemia

Question 40

Sites of hematopoiesis

Answer 40

Yolk sac, spleen, bone marrow (all bones and then membranous bones)