Hematopoeisis Flashcards Preview

Hematology Module 2 > Hematopoeisis > Flashcards

Flashcards in Hematopoeisis Deck (17):
1

Fetal hema place

yold sac

2

hema place after birgh

yolk sac agm, fetal liver, then marrow

3

stem progenitor cell %

4

asymmetric cell division

one daughter cell becomes progenitor other remains stem cell

5

unipotential

committed to one pathway

6

stem and progenitor cell identification

no distinguish morphologically, only through clonal assays

7

LT and ST HSC

Transplantation studies in lethally irradiated mice: LT takes longer, but can give rise to more.

8

CD34

common marker for stem and progenitor cells, except CFUEMk

9

EPO produced where>

Kidney,

10

Hematopoeisis in long bones

absent after age 25 except in proximal ends

11

STEM CELL PROPERTIES

multipotential, high self renewal capacity

12

Stem cell phenotypse (+)

CD34, tHY+, cd49 f+

13

STEM CELL NICHE

OSTEOBLASTIC NICHE SUPPORTS AND MAINTAINS, QUIESCNENCE OR SELF RENEWAL. VASCULAR NICHE PROVIDES SIGNALS.

14

Growth factor functions

produced by stromal cells. Multpiple biological activity (pleotrophic), redundancy, INTERPLAY OF SEVERAL GFS OFTEN INVOLVED, INTERACT WITH MEMBRANE RECEPTORS, COMMONLY ACT SYNERGISTICALLY, PROMOTE SURVIVAL AND DIFFERENTIATION.

15

early acting growth factors

SCF, FL, IL-3, GM-CSF, IL-6, and IL-11.

16

scf

suppresses apoptosis of HSCs and promotes the proliferation and differentiation of stem cells, multilineage progenitor cells, and some committed progenitor cells (CFU-GEMM, GMP, CFU-Mk, BFU-E).

17

FL

(FL) increases recruitment of primitive HSCs/HPCs into cell cycle and inhibits apoptosis.

McKenzie, Shirlyn B.; Williams, Lynne. Clinical Laboratory Hematology (3rd Edition) (Pearson Clinical Laboratory Science Series) (Page 47). Prentice Hall. Kindle Edition.