Hematopoiesis

Question 1

List the Aminoglycans

Answer 1

Hyaluronic acid
Heparan Sulphate
Chondroitin IV Sulphate
Dermatan

Question 2

The aminoglycans are secreted by

Answer 2

Reticulum/adventitia cells
Marrow stroma cells
Adipose cells
Macrophages

Question 3

Hematopoietic growth factors

Answer 3

GCSF
GMCSF

Question 4

Which test indicates the proerythroblast has hemoglobin in it

Answer 4

Fuelgen’s test

Question 5

Which RBC precursors have coin circular nucleus

Answer 5

Proerythroblast
Basophilic erythroblast
Polychromatic erythroblast

Question 6

Which rbc precursor has a pyknotic nucleus

Answer 6

Orthochromatic erythroblast

Question 7

Which organ removes the remnants of organelles from the erythrocyte that leaves the HIM environment ?

Answer 7

Spleen

Question 8

The erythrocyte that leaves the BM is referred to as

Answer 8

Reticulocyte

Question 9

The first morphologically identifiable platelet precursor

Answer 9

Megakaryoblast

Question 10

What is the form of maturation of mrgakaryocytes

Answer 10

Endonuclear reduplication

Question 11

Mediators of Platelet adhesion

Answer 11

vWf, GpIb receptor

Question 12

Mediators of platelet aggregation

Answer 12

fibrinogen
GpIIb, GpIIIa

Question 13

Glanzmann’s disease is deficiency of

Answer 13

GpIIb, GpIIIa

Question 14

Deficiency of GpIb

Answer 14

Bernard Soulier

Question 15

Shape of nucleus of myeloblast

Answer 15

Ovoid/roundish

Question 16

In the ……….., there is development of secondary granule

Answer 16

Myelocyte

Question 17

Basophils, neutrophils and oesinophils become differentials at …………. stage of development

Answer 17

Myelocyte

Question 18

At metamyelocytic stage of development of granulocytes, the nucleus is what shaped

Answer 18

Bean-shaped

Question 19

Match the following: basophils, eosinophils, neutrophils to their functions

Answer 19

Alarm clocks, Parasitic infections, Bactericidal agents respectively

Question 20

Examples of opsonins

Answer 20

Immunoglobulins and C3b

Question 21

Macrophages in the brain

Answer 21

Glial cells

Question 22

Macrophages in the BM

Answer 22

Histiocytes

Question 23

Macrophages in the spleen

Answer 23

Follicular dendritic cells

Question 24

Microphages in the skin

Answer 24

Langerhan cells

Question 25

In the kidney, macrophages are

Answer 25

Mesanglial cells

Question 26

Macrophages in the lymphatics are

Answer 26

veil cells

Question 27

Macrophages in the lungs are

Answer 27

Alveolar macrophages

Question 28

The lymphoid committed stem cell is usually identifiable by a cluster of differentiation antigen called

Answer 28

CD10+

Question 29

Genes present in all tissues of the body are referred to as

Answer 29

GERM LINE INHERITANCE

Question 30

Every B cell in the human body is different because

Answer 30

they express different surface Igs

Question 31

The heavy chain of immunoglobulin has

Answer 31

Variable region Diversity region Joining region Constant region

Question 32

Regions of the light chain

Answer 32

Variable Constant

Question 33

Number of genes in each heavy chain region

Answer 33

V-39-40 D-10 J-6 C-9

Question 34

The kappa or lambda light chain has about (no.of genes in each region)

Answer 34

40 variable 2-3 constant

Question 35

One can have how many plasma cells from one virgin B cell

Answer 35

128

Question 36

The Pre-T cell is identifiable by the expression of T cell specific cluster of differentiation antigens ………

Answer 36

CD 2 CD 3

Question 37

The precortical T cell has which antigens

Answer 37

CD1, CD2, CD3

Question 38

The Cortical T cells is which antigens positive

Answer 38

CD2 CD3 CD4 CD8

Question 39

Antigens of the medullary T cells

Answer 39

CD2 CD3 CD4 or CD8

Question 40

List the T cells that constitute 5% of the T cells in the body

Answer 40

T delayed hypersensitivity cells T suppressor cells T NK cells

Question 41

The T cell mediates

Answer 41

Cellular immunity

Question 42

The T cell possesses what molecule to escape self killing after killing a pathogenic cell

Answer 42

Calci-reticulin molecules

Question 43

Cytolytic proteins of the T cell

Answer 43

Perforins Caspases

Question 44

The T cell uses ……… to identify neoantigen on the pathological cell

Answer 44

TcR

Question 45

The T cell home is the

Answer 45

Paracortex of the Lymph Nodes

Question 46

The B cell home is the

Answer 46

Follicular centre of the Lymph Nodes (where it undergoes further development)

Question 47

You only have cleaved cells in the development of which cells

Answer 47

B cells (only non cleaved cells in T)

Question 48

T immunoblast does not mature any further T/F

Answer 48

T

Question 49

Function of T delayed hyper sensitivity cells

Answer 49

Supply interferon gamma to aid monocyte-macrophage functions against chronic bacterial infections and fungal illnesses

Question 50

Function of T suppressor cells

Answer 50

Limit immune hyperactivity

Question 51

Function of T Natural Killer cells

Answer 51

Cytotic kill on Cancerous/ Mitotic cells

Question 52

Function of Cytotoxic T cells

Answer 52

aka CD8+ Cytotic kill on VIRALLY infected cells

Question 53

Function of macrophages

Answer 53

Immune response against bacterial, fungal and particulate agents

Question 54

Which cell is regarded as the Pivotal Cell of Immunity

Answer 54

CD4+ / Helper T-cells

Question 55

3 types of helper T cells

Answer 55

TH 1 TH 2 TH 17

Question 56

The TH-2 cell is referred to as

Answer 56

The T-regulatory cell

Question 57

Function of TH 1 cell

Answer 57

Effector cell that cytolizes other cells

Question 58

Any human cell expressing CD4 molecule is infectable by

Answer 58

HIV

Question 59

Goals of anti-retro viral therapy

Answer 59

Virologic goal Immunological goal Clinical goal Epidemiological goal

Question 60

Oxygen Tension of Blood is

Answer 60

Amount of O2 present in 100ml of blood

Question 61

With decrease in Hb concentration, what happens to O2 Tension

Answer 61

Reduces