Hematopoiesis and Normal Hemostasis

Question 1

The inner wall of blood vessels is made up of __ cells which secretes substances that activate platelets and coagulation factor

Answer 1

Endothelial cells

Question 2

Specific type of cell which made the endothelial cell

Answer 2

Simple squamous epithelial cells

Question 3

• All blood cells are derived from single progenitor cells
• The widely accepted theory
• The pluripotential hematopoietic stem cells

Answer 3

Monophyletic theory

Question 4

Suggests that all cell lineages have its own stem cell of where it came from

Answer 4

Polyphyletic

Question 5

The hematopoietic stem cell in the bone marrow gives rise to these two common progenitor cells

Answer 5

Myeloid and Lymphoid progenitor cell

Question 6

gives rise to the RBCs, platelets and WBCs (except lymphocytes) precursors

Answer 6

Myeloid Progenitor

Question 7

Also known as the platelet precursor

Answer 7

CFU-MegE

Question 8

platelets are formed through __ of megakaryocytes during thrombopoiesis/platelet shedding

Answer 8

Cytoplasmic fragmentation

Question 9

Platelets has no nucleus but has a part that secretes

Answer 9

Alpha and dense granules

Question 10

Progenitor cell that gives rise to T cell, NK cell and B cell precursor

Answer 10

Lymphoid progenitor

Question 11

State the normal process of hemostasis

Answer 11

Primary Hemostasis > Secondary Hemostasis > FIbrinolysis

Question 12

Blood clot dissolution

Answer 12

Fibrinolysis

Question 13

2 major parts of physiologic hemostatic system

Answer 13

Cellular components and Plasma proteins

Question 14

Cellular components are composed of

Answer 14

Platelets, Endothelial cells, Neutrophils, Monocytes

Question 15

The group of plasma proteins participates in

Answer 15

1. Clot formation
2. Dissolution of clots
3. Inhibition of naturally occurring serine protease