Hematopoiesis (Part I) Flashcards Preview

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Flashcards in Hematopoiesis (Part I) Deck (84)
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1

What does hematopoiesis begin with?

the pluripotent stem cell

2

What is the first split off of the pluripotent stem cell?

it will become either a myeloid stem cell or a lymphoid stem cell

3

What stems from the myeloid stem cell?

erythroblasts, megakaryoblasts, monoblasts, and myeloblasts

4

what is derived from erythroblasts?

RBCs

5

what is derived from megakaryoblasts?

platelets

6

what is derived from monoblasts?

monocytes

7

What is derived from myeloblasts?

neutrophils, eosinophils, and basophils

8

What stems from the lymphoid stem cell?

a pre-B cell and a Prothymocyte

9

what is derived from the prothymocyte?

a T lymphocyte

10

What are the different sites of hematopoiesis in chronological order?

yolk sac, liver, spleen, and then finally the bone marrow

11

What happens to hematopoiesis shortly after puberty?

prior to puberty, hematopoiesis occurs throughout all bones in the body; however, shortly after puberty, hematopoiesis occurs in more of an axillary location including the skull, sternum, ribs, vertebrae, pelvis, and proximal femur

12

Within the bone marrow, there are two principal compartments. What are they?

the hematopoietic cell compartment and the marrow stromal compartment

13

What does the hematopoietic cell compartment of the bone marrow consist of?

an erythroblastic area, a myeloid area, megakaryocytes

14

What does the marrow stromal compartment consist of?

endothelial cells, adipocytes, stromal cells and fibroblasts, and macrophages

15

what is the purpose of the endothelial cells in the marrow stromal compartment?

they are fenestrated, so they allow the mature cells to come out into the circulation and become our peripheral blood

16

what is the main role of all of the stromal compartment cells?

they are responsible for helping us produce the hematopoietic growth factors

17

how can you calculate the percentage of cellularity a person should have in their bone marrow? and what does this tell us?

you subtract their age from 100; this helps us calculate to see if someone's bone marrow is hypocellular or hypercellular

18

How is the process of hematopoiesis regulated?

hematopoietic growth factors

19

where are hematopoietic growth factors produced?

in bone marrow by endothelial cells, stromal cells, fibroblasts, developing lymphocytes, and macrophages

20

what are the chief hematopoietic growth factors?

colony-stimulating factors (CSF), cytokines (interleukins), erythropoietin (EPO), Thrombopoietin (TPO)

21

what is the first potentiator of hematopoietic differentiation?

stem cell factor (SCF)

22

what is stem cell factor produced by?

fetal tissues and bone marrow

23

what is the main role of stem cell factor (SCF)?

it makes stem cells responsive to other cytokines

24

What interleukins act as hematopoietic growth factors?

IL-3, IL-6, IL-2

25

what is the role of IL-3 as a hematopoietic growth factor?

it influences the replication and growth potential of hematopoietic progenitors (non-lymphoid stimulator)

26

what is the role of IL-6 as a hematopoietic growth factor?

it stimulates megakaryocytes and neutrophil production; it is a key factor in leukemoid reaction; it acts as a B-cell growth factor

27

what is the role of IL-2 as a hematopoietic growth factor?

it acts as a B and T cell growth factor

28

What is G-CSF?

granulocyte colony-stimulating factor

29

what is G-CSF produced by?

endothelial cells, fibroblasts, and macrophages

30

what is the role of G-CSF?

it stimulates an increase in neutrophils