Hematopoietic Disorders Flashcards
(20 cards)
Cancers of mature B, T and NK cells
non Hodgkins lymphoma
7 the most common cause of cancer deaths
Non Hodgkins lymphoma
Non Hodgkins lymphoma rises steadily after which age ?
40
Non Hodgkins lymphoma most common in children is?
DLBCL and BL
Non Hodgkins lymphoma in adults is?
DLBCL and FL
EBV causes which lymphoid malignancies?
Burkitts, post-organ transplant lymphoma, primary CNS diffuse large B cell lymphoma, extra nodal NKT lymphoma
What are B symptoms in Non Hodgkins lymphoma
Fever, night sweats,
unexplained weight loss
what are the independent prognostic factors in NHL?
B2 microglobulin level and serum lactate dehydrogenase
for accurate staging to assess lymphadenopathy for indolent lymphomas these imaging modalities are used
Chest, abdominal and pelvic CT scans
this group of B-cell NHL require immediate or urgent tx w chemo and is potentially curable
aggressive
which is the most common type of aggressive B-cell NHL
NHL and diffuse large B-cell lymphoma
which is the most rapidly proliferative aggressive B-cell NHL
NHL and Burkitt’s lymphoma
This type of B-cell NHL is observed and treated only when they symptoms or signs of organ fun impairment, very responsive to therapy
indolent
Tingible body macrophages - classic starry sky appearance
NHL- Burkitt’s lymphoma
Burkitt’s lymphoma is + for which B antigens
CD-10,19,20,BCL6 and surface immunoglobulin
Tx for Burkitt’s lymphoma
cyclophosphamide, EPOCH-R (rituximab, infusional etoposide/ vincristine/doxorubicin, cyclophosphamide, Prednisone)
most common histologic type subtype of NHL-
Diffuse large B-cell lymphoma
Endemic form of Burkitt lymphoma is tumor of which organ?
Jaw or facial bone that spreads to ovary, testis, kidney and breast esp to bone marrow and meninges
Non endemic form of Burkitt’s lymphoma presents w
ascites, renal,testis and /or ovarian involvement
what’s the standard first line for Large-B cell lymphoma
R-CHOP
