Hematopoietic Growth Factors

Question 1

Interleukin-3 (IL-3)

Answer 1

influences replication and growth potential of hematopoietic progenitors

Question 2

interleukin-2 (IL-2)

Answer 2

t cell growth factor

Question 3

interleukins- 1 and 4

Answer 3

act on pluripotent stems cells to develop lymphoid stem cells

Question 4

interleukins- 2 and 6

Answer 4

b cell growth factor

Question 5

erythropoietin (EPO)

Answer 5

stimulates formation of erythrocytes (RBCs), produced primarily in the kidneys

Question 6

thrombopoietin (TPO)

Answer 6

stimulates an increase in megakaryocytes and platelets, produced in the liver

Question 7

GM-CSF (granulocyte-macrophage colony-stimulating factor)

Answer 7

• produced by endothelial cells, T cells, fibroblasts, and monocytes
• stimulates formation of leukocytes and reticulocytes
• needed for formation of neutrophils, eosinophils, basophils, and monocytes

Question 8

G-CSF (granulocyte colony-stimulating factor)

Answer 8

• produced by endothelial cells, fibroblasts, and macrophages
• stimulates an increase in neutrophils
• treatment for neutropenia after chemotherapy, bone marrow transplant

Question 9

M-CSF (macrophage colony-stimulating factor)

Answer 9

stimulates an increase in monocytes and macrophages

Question 10

interleukin-5 (IL-5)

Answer 10

eosinophil progenitors require, basophil progenitors DO NOT

Question 11

GATA-1

Answer 11

required for terminal differentiation to erythroid lineage

Question 12

GATA-3

Answer 12

required for T cell development

Question 13

Pax 5

Answer 13

required for B cell development

Question 14

Ikaros

Answer 14

required for T and B cell development