Heme Flashcards
What two things does Factor XIIa activate?
Factor XI
Converts prekallikrein=>Kallikrein
(Kallikrein cleaves plasminogen to form plasmin)
What is the 2 functions of Kallikrein and what activates it?
Cleaves plasminogen to form plasmin
Converts HMWK=>bradykinin
Activated by Factor XII
What are the steps of the intrinsic pathway?
XII=>XI=>IX=>X=>II =>Fibrin, XIIIa
VIII aids in conversion of IX=>X
V aids in conversion of X=>II
What are the steps of the extrinsic pathway?
VII=>X=>II=>Fibrin, XIIIa
What is the function of plasmin?
Clot buster
-breaks down the fibrin mesh in blood clots
What factor kicks off both the coagulation cascade and the fibrinolytic system?
Factor XII
What are the functions of bradykinin?
Vasodilation
Increases vascular permeability
Pain mediator
What enzyme degrades bradykinin?
ACE is responsible for degrading bradykinin
-ACEI leads to increased bradykinin=>hypotension, angioedema
Will hemophilia affect PT or PTT?
PTT
Hemophilia A: factor VIII def
Hemophila B: factor IX def
-both are in the intrinsic pathway=>PTT
What coag factor is deficient in hemophilia A?
Factor VIII
“Ate”
What coag factor is deficient in hemophilia B?
Factor IX
“Benign”
What is the clinical consequence of a deficiency in either protein C or protein S?
Hypercoagulability
-Warfarin therapy + Protein C deficiency => skin necrosis
MC leukemia in kids
ALL
MC leukemia in adults
CLL
Characteristic Auer rods
AML
