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Step 1 prep > Pharm MOA only > Flashcards

Pharm MOA only Flashcards

1
Q

Bevacizumab

A

Monoclonal Ab against VEGF

-inhibits angiogenesis

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2
Q

Methotrexate

A

DHFR inhibitor

  • Folic acid analogue
  • inhibits pyrimidine synthesis
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3
Q

5-Flourouracil

A

Inhibits Thymidilate synthase

-inhibits pyrimidine synthesis

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4
Q

Cytarabine

A

Inhibits DNA polymerase

-pyrimidine analogue (CyTarabine)

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5
Q

Azathioprine/6-MP

A

Inhibit de novo purine synthesis

  • Purine analogues
  • Metabolized by XO (increased toxicity with allopurinol use)
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6
Q

Dactinomycin

A

Intercalates DNA

-Kids ACT out (Wilms tumor, Ewing sarcoma, Rhabdomyosarcoma)

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7
Q

Doxorubicin/Daunorubicin

A

Generates free radicals, DNA intercalator

  • AE of cardiotoxicity
  • Dexrazoxane used to prevent cardiotoxicity
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8
Q

Bleomycin

A

Free radical generation

-Pulmonary fibrosis

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9
Q

Cyclophosphamide/Ifosfamide

A

Alkylates DNA at N-7 Guanine

-hemorrhagic cystitis => mesna

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10
Q

Nitrosureas (carmustine, lomustine…)

A

DNA alkylators

  • Cross BBB (used on brain tumors)
  • CNS toxicity
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11
Q

Busulfan

A

DNA alkylator

-Pulmonary fibrosis

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12
Q

Vincristine/Vinblastine

A

Inhibit microtubule formation

  • binds beta-tubulin and prevents it’s polymerization into microtubules
  • Peripheral neuritis, bone marrow suppression
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13
Q

Paclitaxel

A

Hyperstabilize microtubules so they can’t be broken down

-mitotic spindle can’t be broken down (stuck in M phase)

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14
Q

Cisplatin/Carboplatin

A

Cross-links DNA

  • Nephrotoxicity, Ototoxicity
  • Prevent Nephrotoxicity with amifostine (free radical scavenger) and chloride diuresis
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15
Q

Etoposide/Teniposide

A

Inhibits Topoisomerase II

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16
Q

Irinotecan/Topotecan

A

Inhibits Topoisomerase I

17
Q

Hydroxyurea

A

Inhibits ribonucleotide reductase

-Prevents DNA synthesis (S phase specific)

18
Q

Predisone/Prednisolone

A

May trigger apoptosis in cancer cells, immunosuppressants

-AE: cushingoid symptoms

19
Q

Tamoxifen/Raloxifene

A

SERMs -block estrogen binding to receptor

  • Receptor antagonist in breast and agonist in bone
  • Risk of endometrial cancer with Tamoxifen due to partial agonist effect on endometrium (no risk with raloxifene)
20
Q

Trastuzumab

A

Antibody against HER2 tyrosine kinase receptor

-cardiotoxicity

21
Q

Imatinib

A

Tyrosine kinase inhibitor of bcr-abl and c-Kit

22
Q

Rituximab

A

Monoclonal Ab against CD20 (found on B cells)

23
Q

Vemurafenib

A

Inhibits BRAF kinase with V600E mutation

Step 1 prep (14 decks)

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