Flashcards in Heme Degradation Deck (13):
I like to divide lectures into categories. The heme degradation lecture can be divided into three categories
(1) Heme metabolism (Heme --> unconjugated bilirubin)
(2) Conversion of unconjugated bilirubin conversion to conjugated bilirubin
(3) Metabolism of conjugated bilirubin
(two fates - reabsorption or excretion)
What is the Van den bergh reaction?
A coupling of bilirubin with a diazonium salt to form a colored complex
What compound does biliverdin reductase require?
Describe the conjugationof biliruubin?
Bilirubin is conjugated to glucoronic acid in the liver
What is Gilbert?
reduction in transcriptin of HDP-GT due to a mutation in the promoter region
What is Criggler-Najjar Syndrome: Type-1?
Complete absence UDP-GT gene
What is Criggler-Najjar Syndrome: Type II?
Mutation in UDP-GT
What is Dubin-Johnson?
Mutation in MRP2
What is Rotor?
Biallelic inactivating in OAT1B1 & OAT1B3
Which compound produced by intestinal bacterial degradation of
conjugated bilirubin gives its yellow color?
Urobilinogen (colorless) but is converted to Urobilin (yellow color of urine) in the kidney