Flashcards in Heme Degradation and Jaundice Deck (14):
What is the enzyme that begins heme degradation?
What transports bilirubin in the blood?
What three drugs displace bilirubin from albumin in the blood?
Once bilirubin is within the hepatocyte, what does it bind to?
Ligandin (intracellular protein)
What is used to conjugate biliruibin?
What is another name for conjugated bilirubin?
What is defective in Dubin-Johnson syndrome?
MRP2 transporter (ABC transporter) that transports conjugated biirubin from the hepatocyte into the biliary caniliculus.
Why are the feces of newborns of a clayish gray color?
There is no urobilinogen in the gut of fetuses and urobiligen is what leads to stericobilinogen (which leads to brown color)
(T/F) Bilirubin is covalently bound to albumin
What reagent is used in lab tests to detect conjugated bilirubin?
Which enzyme deficiency leads to the physiological jaundice of the newborn?
Bilirubin UDP-glucuronyl transferase
What is the clinical sign of jaundice?
Yellowish discoloration of the:
and nail beds
(due to: bilirubin binds to connective tissue)
How is posthepatic Jaundice different from
Post: no increase in unconjuated bilirubin