Heme Degradation and Jaundice Flashcards Preview

Medical Biochemistry > Heme Degradation and Jaundice > Flashcards

Flashcards in Heme Degradation and Jaundice Deck (14):
1

What is the enzyme that begins heme degradation?

Heme Oxygenase

2

What transports bilirubin in the blood?

Albumin

3

What three drugs displace bilirubin from albumin in the blood?

Salicylate
Asprin
Sulfanomides

4

Once bilirubin is within the hepatocyte, what does it bind to?

Ligandin (intracellular protein)

5

What is used to conjugate biliruibin?

UDP-glucuronic acid

6

What is another name for conjugated bilirubin?

Bilirubin diglucuronide

7

What is defective in Dubin-Johnson syndrome?

MRP2 transporter (ABC transporter) that transports conjugated biirubin from the hepatocyte into the biliary caniliculus.

8

Why are the feces of newborns of a clayish gray color?

There is no urobilinogen in the gut of fetuses and urobiligen is what leads to stericobilinogen (which leads to brown color)

9

(T/F) Bilirubin is covalently bound to albumin

False

10

What reagent is used in lab tests to detect conjugated bilirubin?

Diazo reagent

11

Which enzyme deficiency leads to the physiological jaundice of the newborn?

Bilirubin UDP-glucuronyl transferase

12

What is the clinical sign of jaundice?

Yellowish discoloration of the:
skin
mucous membranes,
sclera
and nail beds

(due to: bilirubin binds to connective tissue)

13

How is posthepatic Jaundice different from

Post: no increase in unconjuated bilirubin

14

What is the injury marker for complete obstructive jaudice?

serum ALP
color of urine is orange/reddish/brown