Medical Biochemistry

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Decks in this class (35)

Post Midterm Drugs
Methotrexate,
Sulfanomides,
Trimethoprim
61  cards
Post Midterm Diseases
Pku,
Alkaptonuria,
Tyrosinemia type 1
31  cards
Nutrition
Give a general description of vit...,
Describes the steps of the absorp...,
List the sources of vitamin a
302  cards
GAGs and Proteoglycans
What are glycosaminoglycans gags,
What type of matrix do gags have,
What causes gags to have a gel li...
92  cards
Lysosomal Storage Disorders
What is the deficient enzyme in h...,
Which substrates accumulate in hu...,
What diagnostic method do you use...
52  cards
Lipid Mobilization and Catabolism; Ketone body synthesis and utlization
Fatty acids in tag are released a...,
What inhibits hormone sensitive l...,
Deficiency of what hormone during...
104  cards
Fatty Acid and Triacylglycerol Metabolism
What are the two main sites of fa...,
What can be achieved by fatty aci...,
Which metabolic condition leads t...
46  cards
Metabolic response to trauma/ critical illness
What are the various factors that...,
What are hormonal mediators of st...,
What is the role of aldosterone
67  cards
Eicosanoids
What is the major site of synthes...,
What are the major biological act...,
What is the major site of synthes...
47  cards
Cholesterol and Steroid Metabolism
What are the important functions ...,
Describe the structure of cholest...,
Where is the site of attachment o...
72  cards
Steroids
•Name the five classes of steroid hormones (glucocorticoids, mineralocorticoids, androgens, estrogens and progestins) •Discuss steroid hormone synthesis related to STAR and desmolase (CYP11A) •Describe the steroid hormones synthesized and released from the adrenal cortex (specified for zona fasciculata, z. glomerulosa and z. reticularis) •Indicate the synthesis and the metabolic actions of cortisol •Indicate the synthesis and the metabolic actions of aldosterone •Indicate the sy
50  cards
Lipoprotein Transport
Describe the transport of free fa...,
How are tags and cholesteryl este...,
How are dietary lipid soluble vit...
113  cards
Introduction to Nitrogen Metabolism and Metabolism of Amino Acids
Nitrogen can be released by kidne...,
Which enzyme converts phenylalani...,
Deficiency of which amino acid ma...
70  cards
Inherited disorders of amino acid catabolism
•Outline the catabolic pathway of the following amino acids: –Phenylalanine and tyrosine and associated disorders •Phenylketonuria(Classic-PKU I and tetrahydrobiopterindeficiency –PKU II, maternal PKU), Alkaptonuria, Tyrosinosis –Branched chain amino acids •Maple syrup urine disease •Methylmalonicaciduria –Methionineand cysteine •Homocystinuria •Outline the two possible fates of homocysteine •For each of the disorders listed above –Specify the enzyme deficient and coenzyme requ
40  cards
Ammonia and the Urea Cycle Specialized N-products
What is the deficient enzyme in h...,
What is the deficient enzyme in h...,
What is the deficient enzyme in c...
30  cards
Specialized Products of Amino Acids
Tyrosine is converted to what by ...,
Dopa is converted to what by what...,
Dopamine is converted to what by ...
31  cards
The Feed-Fast Cycle: Role of Hormones
Objectives: i.Explain metabolic homeostasis and describe the mechanisms involved in the inter-tissue integration required for metabolic homeostasis ii.Differentiate between the postprandial phase, the post-absorptive phase and the early phase of starvation. iii.Explain the special role of glucose in metabolic homeostasis iv.Describe in general the pathways leading to fatty acid synthesis and cholesterol synthesis in the fed state starting with glucose v.Describe the roles of insulin and glu
34  cards
Vitamin B12 and Folic Acid
–Specify the one-carbon donors in metabolism and the groups they donate (SAM, THF, Cobalamin) –Explain the formation of SAM and the reactions requiring SAM –Analyze the metabolism of homocysteine, vitamins/ coenzymes required for metabolism & interpret the clinical significance of homocysteine –Explain the formation of THF from folate and specify the mechanism of action of their inhibitors –Summarize the formation of one carbon groups from amino acid metabolism and the utilization of 1-C gro
37  cards
Nucleotide Metabolism (Purines)
•Identify the differences between N-base, nucleoside and nucleotide with examples •Regarding purinebiosynthesis –Enumerate the C & N donors of the purinering (amino acids and 1-C groups) –Outline purinebiosynthesis –Discuss the regulation of purinebiosynthesis (Identify the regulatory enzyme and positive and negative modulators) –Correlate the mechanism of action of sulfadrugs, trimethoprim, methotrexate, mycophenolicacid to their clinical application –Explain the formation of deoxyribonuc
43  cards
Hypoglycemia
Hypoglycemia is characterized by ...,
What can cause adrenergic symptoms,
What can cause neuroglycopenia sy...
37  cards
Nucleotide Metabolism (Pyrimidines)
–Enumerate the donors of C & N atoms to pyrimidine ring –Outline pyrimidine biosynthesis (UTP & CTP). Distinguish purine and pyrimidine biosynthetic pathways –Summarize the regulation of pyrimidine biosynthesis (regulatory enzymes, regulators) –Indicate the formation of deoxyribonucleotides from ribonucleotides –Explain the synthesis of dTMP –Indicate the mechanism of action of 5 fluoro uracil and methotrexate and their clinical application –Regarding orotic aciduria •Specify enzyme defic
15  cards
Molecular mechanisms in inherited disorders
Mutation in what proteins results...,
What is cftr,
Cftr belongs to what group of tra...
81  cards
Heme Synthesis: Porphyrias
Objectives: i.Describe in detail ALA synthaseand ALA dehydratasereactions ii.Outline hemesynthesis starting from glycineand succinylCoAto the formation of heme iii.Distinguish between the different regulatory processes of hemesynthesis in the liver and in the erythroidcells iv.Explain how pyridoxine deficiency affects hemesynthesis v.Discuss the effects of lead poisoning on hemesynthesis vi.Categorize the different types of porphyriasbased on clinical manifestations such as abdominal pain,
15  cards
Heme Degradation and Jaundice
Objectives: Hemedegradation and jaundice •Outline the steps in the degradation of hemeto bilirubinin the macrophages. •Explore the relationship of serum albumin and the transport of bilirubin •Explain the biochemical consequence of a block in each of the steps in the uptake and conjugation of bilirubinin liver. Distinguish the activity of UDP-glucuronyltransferasein adults versus premature babies. •Analyze the steps in the processing of conjugated bilirubinin the intestine and its excretion
14  cards
Serum Proteins and associated disorders - Part 1
Objectives: i.Describe how plasma proteins can be separated by electrophoresis and classify plasma proteins based on electrophoreticmobility ii.Describe the functions of serum albumin and globulins iii.Indicate the role of proteins of the complement system iv.Predict the common causes of hypoalbuminemia(liver disease, nephroticsyndrome, protein malnutrition) and explain the biochemical basis for the occurrence of edema in hypoalbuminemia v.Distinguish the functions of proteins that are foun
39  cards
Serum Proteins and associated disorders - Part 2
Objectives: i.Describe how plasma proteins can be separated by electrophoresis and classify plasma proteins based on electrophoreticmobility ii.Describe the functions of serum albumin and globulins iii.Indicate the role of proteins of the complement system iv.Predict the common causes of hypoalbuminemia(liver disease, nephroticsyndrome, protein malnutrition) and explain the biochemical basis for the occurrence of edema in hypoalbuminemia v.Distinguish the functions of proteins that are foun
29  cards
Heme Synthesis, Degradation and Porphyrias - Part 1
In which cells is heme mainly syn...,
What is the difference between he...,
What is the general concept of he...
32  cards
Heme Synthesis, Degradation and Porphyrias - Part 2
What are erythropoietic porphyrias,
What are two examples of erythrop...,
What are two examples of hepatic ...
20  cards
Heme synthesis, Degradation and Porphyrias - Part 3
Does heme degradation start in ma...,
What is the name of the enzyme th...,
Does heme oxygenase form carbon m...
23  cards
Heme synthesis, degradation and porphyrias - Part 4
Conjugated bilirubin is also know...,
Where and how is urobilinogen formed,
What leads to the brown sterobili...
22  cards
Hemostasis: Blood coagulation and fibrinolysis - Part 1
Objectives: Hemostasis •Outline the four phases of hemostasis. •Discuss vascular spasm and the role of endothelin. •Describe the platelet plug formation. •Explain the role of integrins GPIb and GPIa. •Describe the role of platelet-activating factors (ADP, serotonin, TXA2and thrombin). •Describe the role of integrinGPIIb/IIIain platelet aggregation. •Describe the coagulation cascade, including the extrinsic, intrinsic and common pathways. •Indicate the role of calcium in hemostasis •Disc
20  cards
Hemostasis: Blood coagulation and fibirinolysis - Part 2
In general the aim of the third s...,
The conversion of fibrinogen to f...,
The formation of thrombin occurs ...
33  cards
Hemostasis: Blood coagulation and fibrinolysis - Part 3
What occurs in general in the fib...,
What protein is incorporated into...,
What factors cause inactive plasm...
32  cards
Hemostasis: Blood Coagulation and Fibrinolysis - Part 4
Which bleeding disorders are due ...,
Which bleeding disorders are due ...,
In hemophilia there which is an x...
14  cards
Liver Function Tests - Part 1
Objectives: Liver function tests •List the important functions of the liver –Excretion of bilirubin –Synthesis of plasma proteins –Detoxification of ammonia •Interpret the values of the following laboratory tests in the diagnosis, follow up and prognosis of a patient with liver disease (acute hepatitis, alcoholic liver disease, cholestaticdisease) –Serum (total, conjugated and unconjugated) and urine bilirubin –Serum enzymes (ALT, AST, GGT, 5’NT, LDH) –Serum proteins (albumin and globuli
29  cards

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Medical Biochemistry

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