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ABFM/Rosh Review > Heme/ONC > Flashcards

Flashcards in Heme/ONC Deck (6)
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1

Von Willebrand dz, Protein C def, hemophilia A & B

PTT, PT, bleeding time, platelets?

-VWD: normal platelets, PT/INR & aPTT
-Hemophilia A/B: nomal platelets, PT, bleeding time. Prolonged PTT
-Protein C: def causes DIC = prolonged bleeding time, low platelets & increased PT & PTT

2

When do you see Howell jolly bodies?

Howel jolly = nuclear remnants/DNA. Seen anytime you have significant reticulocytosis.
-aspleenia, spleen trauma,autospleenectomy/sickle cell anemia, megaloblastic anemia, hereditary spherocytosis, myelodysplastic syndrome

3

When do you see basophilic stippling? what is it?

Basophilic stipling is aggregation of residual ribosomes = toxic injury to bone marrow such as in lead poisoning or megaloblastic anemia.

4

When do you see burr cells?

occurs when RBC have abnormal cell membranes.

5

When do you see Heinz bodies? what are they?

denatured globin chains within RBC. seen with G6PD deficiency

6

Beta Thalassemia hemoglobin electrophoresis will show….

Reduced or absent HgAlpha, increased HgA2 and increase HgF