Heme, Porphyrin, and Hemoglobin Flashcards Preview

Clinical Chemistry > Heme, Porphyrin, and Hemoglobin > Flashcards

Flashcards in Heme, Porphyrin, and Hemoglobin Deck (12)
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1
Q

Essential mineral to most living organisms which is the most abundant trace element and it is combined with heme to provide stable hemoglobin synthesis

A

Iron

2
Q

How many of the 3-5 grams of iron in our bodies is found in hemoglobin?

A

2-2.5

3
Q

Regulation of iron is done through

A

• Dietary sources
• Absorption
• Iron “stores”
→ Iron is recycled when RBCs are broken down

4
Q

Iron is absorbed in what state and where

A

ferrous state (Fe2+) in stomach or small intestines

5
Q

Where is 25% of iron stored in?

A

liver, spleen and bone marrow as FERRITIN (FE3+)

6
Q

T or F: Iron supplements will immediately raise hb levels

A

false, at least 6-8 weeks before changes are observed; not all iron is observed

7
Q

Functions of iron

A

• Essential element of heme and hemoglobin
• Iron is not only found in hemoglobin
→ Component of methemoglobin, myoglobin, and some enzymes
• Cellular oxidative mechanisms
• Fetal Hemoglobin
→ Babies have this instead of the hemoglobin adults have

8
Q

T or F: fetal hemoglobin has higher affinity for oxygen

A

true

9
Q

What are the storage proteins of iron?

A

Ferritin (soluble)

Hemosiderin (insoluble)

10
Q

What are the transport proteins of iron?

A

Apotransferrin

Transferrin

11
Q

Storage protein which is the protein shell surrounding an iron core

A

Ferritin

  • can convert iron inside the core into ferric iron for distribution to body cells
  • provides a reserve of iron for formation of hemoglobin etc.
12
Q

Partially deproteinized ferritin

A

hemosiderin