Hemolytic Disease of the fetus and newborn

Question 1

1. The most common type of HDFN is due to antibodies
   of the
   a. Kell system
   b. Kidd system
   c. Lewis system
   d. Rh system

Answer 1

d. Rh system

Question 2

2. Which class of antibodies causes HDFN?
   a. IgA
   b. IgD
   c. IgG
   d. IgM

Answer 2

c. IgG

Question 3

3. In HDFN, the greatest risk to the fetus prior to birth is
   due to
   a. anemia
   b. hyperbilirubinemia
   c. an enlarged head
   d. bleeding

Answer 3

a. anemia

Question 4

4. After birth, the infant with severe HDFN is at risk for
   which of the following?
   a. bleeding
   b. brain damage
   c. anemia
   d. enlarged head

Answer 4

b. brain damage

Question 5

5. The most common method of determining fetal
   anemia is
   a. amniotic fluid analysis
   b. cordocentesis
   c. middle cerebral artery Doppler
   d. analysis of maternal serum

Answer 5

c. middle cerebral artery Doppler

Question 6

6. Since mapping of the human genome, the theory of Rh
   inheritance is based on
   a. one gene—Rh
   b. two genes—RHD and RHCE
   c. three genes—D, C/c, and E/e
   d. five genes—D, C, c, E, and e

Answer 6

b. two genes—RHD and RHCE

Question 7

7. Titration studies are most predictive of the severity of hemolytic disease
   a. during the first affected pregnancy
   b. when the antibody is anti-K
   c. when there is a one tube difference between the
   current and most recent past specimen
   d. if the titration is done using enzyme enhanced indicator cells

Answer 7

a. during the first affected pregnancy

Question 8

8. The primary intent of an intrauterine transfusion is to
   a. prevent kernicterus
   b. prevent graft-versus-host disease
   c. increase the albumin in the fetus to prevent hemolysis
   d. increase the fetal hematocrit to prevent hydrops

Answer 8

d. increase the fetal hematocrit to prevent hydrops

Question 9

9. The rosette test is used to
   a. screen for fetal lung maturity
   b. screen for massive fetomaternal hemorrhage
   c. screen for IgG antibodies
   d. quantitate massive fetomaternal hemorrhage

Answer 9

b. screen for massive fetomaternal hemorrhage

Question 10

10. The principle of the K–B test is resistance
    a. of fetal hemoglobin to acid solutions
    b. of fetal hemoglobin to alkaline solutions
    c. adult hemoglobin to alkaline solutions
    d. adult hemoglobin to acid solutions

Answer 10

a. of fetal hemoglobin to acid solutions

Question 11

11. Cellular blood components for infants who have had an
    intrauterine transfusion are irradiated to prevent
    a. sickle cell formation
    b. CMV transmission
    c. graft-versus-host disease
    d. high potassium in the product

Answer 11

c. graft-versus-host disease

Question 12

12. The test that may not be positive in ABO HDNF is
    a. direct antiglobulin test
    b. rosette test
    c. Kleihauer–Betke
    d. Antibody-screening cells

Answer 12

a. direct antiglobulin test

Question 13

13. A paternal specimen is most useful in identifying HDNF
    cause by antibodies directed against
    a. Low-incidence antigens
    b. Rh antigens
    c. High-incidence antigens
    d. antiplatelet antibodies

Answer 13

a. Low-incidence antigens

Question 14

14. The K–B result is 15 cells. The dose of Rh immune globulin needed to prevent sensitization to anti-D in an Rh
    positive woman is
    a. none
    b. 1 vial
    c. 2 vials
    d. 3 vials

Answer 14

c. 2 vials

Question 15

15. NAITP is a condition in which a
    a. mother develops specific platelets antibodies that destroy fetal platelets
    b. mother develops nonspecific antibodies to platelets
    that destroy fetal platelets
    c. fetus develops anti-PlA1
    d. fetus develops nonspecific platelet antibodies

Answer 15

a. mother develops specific platelets antibodies that
destroy fetal platelets