Hep B Flashcards
(15 cards)
1
Q
epidemiology
A
- most common globally
- sub saharan africa, Asia and pacific islands
- decline in uk bc of vaccination
2
Q
transmission
A
- infected blood or body fluids
- vaginal / anal
- passing to feautus
3
Q
progression and presentation
A
children 90% chronic <6yrs
adults 10% chronic
- jaundice
- fever
- malaise
- potential darkening of urine and lightening of stool
chronic - not cleared after 6 months - decompensated liver failure
4
Q
investigations
A
- HBsAg present >6 months - carrier
- HBeAg - most infectious when +
- HBeAg -ve may get immune escape phase even in the presence of HBe antibodies
5
Q
HBsAg
A
indicated current infection - persists >6 months
6
Q
anti-HBs antibody
A
immunity from past infection or vaccination
7
Q
HBeAg
A
indicates active viral replication - higher infectivity
8
Q
anti-HBe antibody
A
- lower infectivity
- reduced viral replication
9
Q
HBcAb
A
IgM - acute infection
IgG - past infection / vaccination
10
Q
HBV DNA
A
quantifies viral load - used to monitor response to treatment
11
Q
biopsy
A
ground glass hepatocytes
12
Q
treatment
A
- pegylated interferon alpha-2a
- tenofovir
- entecavir
13
Q
vaccine?
A
yes
14
Q
viral
A
hepatinivirus dsDNA
15
Q
chronic results part
A
IgM neg
IgG pos
