Hepatic Flashcards

Get to know yo liva! (70 cards)

1
Q

What is cholecystitis

A

inflammation of gall bladder

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2
Q

can acute cholecystitis become chronic?

A

Siiii

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3
Q

What are most of the gallstones made of?

A

Cholesterol

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4
Q

TYpes of gallstones

2

A
  1. cholesterol

2. pigmented

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5
Q

What are pigmented gallstones made from

2

A

Bilirubin or hemolysis

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6
Q

5 diseases that can progress to cirrhosis

A
  1. Fatty Liver
  2. Hepatitis
  3. Biliary DIsease
  4. metabolic Disease
  5. vascular
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7
Q

What things cause fatty liver

A
  1. ETOH
  2. Obesity
  3. DM
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8
Q

What causes Hepatitis

A
  1. Virus
  2. Drug
  3. Autoimmune
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9
Q

What is the liver made of

A

Hepatocytes
Duct cCells
Blood Vessels

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10
Q

What is the triad

A

Bile duct
Portal vein
Hepatic Artery

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11
Q

Blood path

A

Sinusoids -> where it enriches hepatocytes
Central Vein
Heart -> its recycled

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12
Q

What does the metabolic work in liver

A

hepatocytes

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13
Q

WHat is the #1 casue of liver toxicity

A

Drugs!

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14
Q

Steatosis aka

A

Fatty Liver

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15
Q

What is the worst type of destruction of the liver?

A

Fibrosis

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16
Q

Why is fibrosis so bad

A

Collagen Scar

Permanent Injury

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17
Q

What is end stage of fibrosis in liver

A

cirrhosis

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18
Q

If hepatocytes die in large sheets, what happens to those areas

A

fill up with blood

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19
Q

what if blood in liver builds up

A

It can back-flow and cause heart failure

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20
Q

What is cholestasis

A

decrease in bile production due to less secretion or obstruction

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21
Q

If canaliculi in liver fill with bile bc of cholestasis then what

A

person gets jaundice

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22
Q

what is hepatatis

A

inflammation of the liver

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23
Q

Is hepatitis contagious

A

if caused by virus, yes

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24
Q

What can cause hepatitis beside viruses

A

toxins

drugs

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25
What drugs cause hepatitis
ETOH | acetaminophen
26
What type of hepatitis resolves itself
acute
27
acute hep by what viruses doesn't progress to chronic
Hep A and E
28
acute hep by what viruses progress to chronic and beyind
Hep B, C and D
29
what type of hep virus is rarely expressded
Hep D
30
Hep B, C and D can progress to what 3 things
chronic hep cirrhosis hepatocellular carcinoma
31
how long is acute hep vs chronic
acute <6mo
32
what type of inflammation in acute vs chronic hepatitis
acute - lobular inflammation | chronic - portal inflammation
33
What type of fibrosis in acute vs chronic hep
acute - no fibrosis | chronic - fibrosis
34
what virus causes hep a
picornavirus
35
what virus causes hep e
calcivirus
36
what virus causes hep b
hepadnavirus
37
whatvirus causes hep c
flavivirus
38
what virus casues hep d
deltavirus
39
what are syptoms of hep c during acute stage
Noooneee
40
how is hep c easily transmitted
blood | needles
41
tx of hep c
very expensive combination of antivirals
42
what immunization prevents hep c
no immunization available
43
How is hep B trasnmitted
blood
44
what symptoms in hep B during acute phase
Noooneee
45
what is the most common blood-borne infection among healthcare workers
Hep B
46
what is hep B associated with
a lot of hepatocellular carcinoma
47
Tx of hep B
Immunization | Antivirals
48
Cirrhosis =
regenerative hepatocyte nodules
49
where is fibrosis in cirrhosis
surrounding nodules
50
autoimmune hepatitis is found hwere
obese, middle aged women
51
autoimmune hep goes onto what
advanced fibrosis
52
what color is a fatty liver
purple | jk, yellow
53
in steatosis fat accumulation in liver is ______ | with ______ cellular damage
temporary | NO
54
steatohepatitis def
damage to the liver with fibrosis present. Chronic
55
metabolic disease in liver is often associated with?
iron overloads
56
wilson's disease is what type of defect
copper metabolic defect
57
wilson's disease course?
hepatitis, then cirrhosis
58
Biliary disease def
destruction of bile ducts causing bile back up into liver. This causes inflammatory cells to surround ducts
59
Biliary disease could end up forming what
Granulomaaas
60
hepatocellular injury causes accumulation of what?
ceroid pigment
61
hepatocellular damage casues accumualtion of ceroid pigment where
Kupffer cells
62
vectors of HBV | 3
blood saliva nasopharyngeal secretions
63
in mouth, where is the highest concetration of HBV
gingival sulcus
64
Manifestations of HBV | 6
1. Lichen Planus 2. Periodontal Disease 3. Candidiasis 4. Increased Oral Bleeding 5. Increased DM type 2 6. Sjorgrens Syndrome
65
Management of accidental exposure to HBV
wash - without rubbing use antiviral disinfectant initiate HBV vaccine
66
Objectives of HCV tx | 2
1. Eliminate virus | 2. Prevent progression to fibrosis and cancer
67
Guidelines for HCV tx | 3
1. Over 18 2. Pt has compensated liver disease 3. Willingness of pt to follow tx requirements
68
how many of ppl treated for HCV remain virus free for 1 yr
92%
69
Tx for HCV is contraindicated on who
pts with severe liver disease due to metabolism problems
70
cost of HCV
90K