Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

AFN Health Assessment > Hepatic/Biliary > Flashcards

Hepatic/Biliary Flashcards

(74 cards)

Start Studying
1
Q

Portal Triad

A

-hepatic arteriole

-portal venule

-bile duct

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Zone 1 of liver receives O2 ______ blood

A

O2 rich

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Zone 3 of liver recieves O2 ______ blood

A

O2 poor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hypoxia effects which zone the most?

A

Zone 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Liver receives ___% of CO

A

25%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Portal vein supplies ____% of hepatic blood flow

A

75%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Hepatic a. supplies ___% of hepatic blood flow

A

25%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Portal v. & hepatic a. each supply ____% of hepatic O2 supply

A

50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Portal v. normally has ____ vasc. resistance

A

low

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The liver, via __________ (large pores in endothelial lining), generates ____% of the bodies lymph

A

sinusoids

50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Alpha 1 stimulation does what to hepatic vasculature?

A

Vasoconstricts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Beta 2 stimuation does what to hepatic vasculature?

A

Vasodilates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

List some of the consequences of portal HTN

A

-Ascites

-hepatic enchephalopathy (d/t shunts limiting ammonia filtration/elimination)

-bacterial peritonitis

-hepatorenal syndrome

-splenomegaly

-varicies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What macrophage cells in the liver cleanse the blood of bacteria?

A

Kupffer cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The liver removes ammonia via the formation of _______

A

Urea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The liver synthesizes all co-ag factors except…..

A

3, 4, 8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Vitamin K absorption, and therefore vitamin K coag factors depend on what?

A

Bile excretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the vit K dependent factors?

A

2, 7, 9, 10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

_________ abnormalities may be more common w/ liver disease

A

endocrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

The liver converts ______ to ______

A

T3 to T4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What 3 things does the liver do w/ bilirubin?

A
  1. absorbs it from blood stream
  2. conjugates it (makes it water soluble)
  3. excretes it via biliary system (bile duct)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Increased risk of post-op _________/_________ w/ liver disease

A

infection/sepsis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Presystemic elimination of drus given via the oral route

A

First-pass effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

3 main goals of hepatic biotransformation

A

-make drugs inactive

-make drugs water soluble

-make drugs ready to secrete

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What phase reaction in hepatic biotransformation makes drugs hydrophilic/more polar
Phase 1
26
What phase reaction in hepatic biotrasformation is suseptible to inhibition by advanced age/hepatic dysfxn
Phase 1
27
What phase reaction in hepatic biotransformation is responsible for drug conjugation?
Phase 2
28
Big take away w/ hepatic pharmacokinetics?
Careful titration of meds!
29
What labs evaluate hepatocyte injury/necrosis?
ALT/AST/GST
30
What labs evaluate hepatic conjugation and excretion?
bilirubin/alkaline phosphatase/GGT
31
What labs evaluate hepatic protein synthesis?
albumin/PT/INR
32
Is albumin a good indicator for acute liver dz?
No (3 week 1/2 life)
33
Sensitive indicators for acute liver dz?
PT/INR
34
PT is dependent on __________ intake
Vit K intake
35
With _________ _________, PT may be prolonged w/ preserved liver fx
biliary obstruction
36
Primary screening exam for liver dz/obstructions
Ultrasonongraphy
37
Originates from breakdown of Hgb
Bilirubin
38
Disorder of bilirubin metabolism, hemolysis, hepatocyte dsfxn leads to increase in which kind of bilirubin?
Unconjugated
39
Gallstones, biliary obstructions lead to what type of bilirubin increase
Conjugated
40
Rarely see bilirubin > ___. Why?
35 Renal systems excretes it also
41
IF bilirubin >35, what concominate disease do you have along with severe liver dz?
Renal failure or sometimes, hemolysis
42
Alcoholic liver dz. usually beningn & resolves w/ abstinence
Steatosis
43
Alcoholic hepatitis can progress to ________
Cirrhosis
44
W/ alcoholic hepatitis, how long should you delay elective surg
12 weeks
45
In alchoholic hepatitis, AST to ALT ratio is __:__
2:1
46
NASH is another name for what disease
Fatty liver dz
47
2 most common causes of cirrhosis
HepC & ETOH
48
What is the halmark CV sypmtoms of Cirrhosis
Hyperdynamic circulation
49
3 hemodynamic signs of hyperdynamic circulation
- Increased HR -Increased CO -Decreased PVR
50
2 Scoring systems that test risk of death from liver dz
MELD & Child-Pugh
51
TIPS procedures helps tx what?
Portal HTN
52
Hep transmitted via fecal/oral
Hep A
53
Sexually & blood transmitted hep type
Hep B
54
Blood borne only Hep types
Hep C&D
55
Ischemia hepatitis is d/t what
Hypoperfusion leading to hypoxia
56
What classification is used specifically for cirrhosis
child-pugh
57
What classficiation is used specifically for liver transplant prioritization
MELD
58
This classficiation system intrigrates weighted values of bilirubin, INR, & creatinine
MELD
59
MELD < ___ and child class ___ means only slight increase risk periop M&M
<8 class A
60
sexual activity risk of hep __
hep B
61
travel risk of hep ___
hep A
62
IV drug us risk of hep ___
hep C
63
tatoo risk of hep ___
hep B
64
Obesity/metabolic syndrome risk of what liver dz
NASH
65
MELD score >___ used to stratify pts on waiting list for liver transplant
>11
66
Main takeaway w/ hepatic encephalopathy
decrease ICP
67
What Na levels needed to maintain w/ hepatic encephalopathy
150-154
68
Leading cause of post-transplant M&M
CV disease
69
Which one is worse, HRS type 1 or 2?
1
70
MELD score above ____ means you should avoid TIPS procedure
24
71
Are acute pancreatitis pts surg candidates?
NOOO
72
Whipple procedure is for what, and what it the main thing you need to remember regarding anesthesia management
Pancreas tumor removal ***Risk for blood loss/fluid shifts ***Use invasive monitoring
73
Normal AST
10-40
74
Normal ALT
10-60

AFN Health Assessment (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions