Hepatic pathophysiology Flashcards Preview

Pathophysiology II > Hepatic pathophysiology > Flashcards

Flashcards in Hepatic pathophysiology Deck (20)
Loading flashcards...
1

What is the basic functional unit of the liver?

lobule

2

About how many lobules are in the liver?

50,000-100,000

3

What 2 blood vessels bring blood to the liver?

portal vein and hepatic artery

4

What blood vessel brings blood out of the liver and where does that blood go?

hepatic vein, goes into IVC and returns to the heart

5

How much of the liver's O2 requirement does the portal vein supply?

50-55%

6

What is the SaO2 of the portal vein?

85%

7

How much of the liver' O2 requirement doe the hepatic artery supply?

45-50%

8

What is normal hepatic blood flow?

1,500 mL/min

9

How much of the body's CO goes to the liver?

25-30%

10

About how many mL/min is delivered to the liver from the portal vein?

1100 mL/min

11

About how many mL/min is delivered to the liver from the hepatic artery?

400 mL

12

What is the portal vein pressure as blood enters the liver?

9 mmHg

13

What is the pressure in the hepatic vein as blood leaves the liver?

0 mmHg

14

The liver has (high/low) blood flow and (high/low) vascular resistance.

high blood flow, low vascular resistance

15

About how long does it take for blood to traverse from the portal vein to the central vein and why is this important?

8-9 seconds, allows sufficient time for the blood to be in contact with hepatocytes and Kupffer cells

16

What controls hepatic artery blood flow?

autoregulation based on metabolic demand

17

What controls portal vein blood flow?

blood flow to the GI tract and the spleen

18

What happens if there is a decrease in blood flow in one of the vessels that supplies blood to the liver?

change in blood flow from one source will produce a reciprocal (but somewhat limited) compensatory change in the blood flow from the other source Ex: dec. in hepatic artery blood flow produces an increase in portal venous blood flow

19

What organs supply blood to the portal vein?

stomach
spleen
pancreas
small intestines
colon

20

How does cirrhosis affect blood flow through the liver?

greatly increases resistance to blood flow, destruction of liver parenchymal cells results in replacement with fibrous tissue that contracts around the blood vessels