Hepatitis SR Flashcards
1
Q
Causes
A
Drugs Vrses Bacteria Autimmune Ischaemic
2
Q
Types of virus
A
HAV - RNA (picornoviridae) HBV - DNA (hepadnaviridae) HCV - RNA (flaviviridae) HDV - RNA (needs HBV, flaviviridae) HEV - RNA - (calciviridae) HGV - RNA - (flaviviridae)
3
Q
HAV
A
- never chronic infection (not more than 6 months)
- acute.
- asymptomatic in child
- no treatment
- more sympomatic patients as age goes up
- faecal - oral route
- vaccine available
- +ve sense RNA, icosahedral capsid, no-enveoped
- incubation period: 4 weeks
4
Q
HBV
A
- acute and chronic infection
- immune tolerance
- child will be asymptomatic but may be chronic/decades
- as child grows older, less get chronic infections because their adaptive immune system is able to respond
- suppresive treatment
- intact virions, artially doube stranded, DNA virus, enveloped, hepatoopic DNA VIRUS, HEPADNAVIRIDAE
- oncogenic
- 3-4 months
5
Q
HCV
A
- acute and chronic
- no vaccine
- curative treatment
- no DNA incorporation
- 6-7 weeks
6
Q
HBV life cycle
A
- HBV attaches and infects the liver cell.
- capsid is removed upon entry
- revers transcriptase makes RNA copes which are then used by ribosomes to form antigens. Eary antigens are secreted.
- pre-genomic RNA is transformed to DNA using polymerse.
- reassembled to be released
- some DNA does get incorporated in the cell genome
7
Q
HAV diagnosis
A
- antibody against HAV.
2. clinical illness IgM, IgG is past infection
8
Q
HBV diagnosis
A
- presence of surface antigens
a. surface Ag
b. Early Ag
c. Core Ag. - if someone has anti HBS IgG and andti HBC by core, they are infected.
- if just anti-HBS but not anti-HBC then it is just vaccination
9
Q
HCV
A
- antibody against HCV - past or present –> PCR, IF NEGTIVE, EXCLUDE.
10
Q
HBV treatment
A
- entecavir
2. tenofovir
11
Q
HCV treatment
A
- interferon
- non-specific antivirals (ribavarin and interferon)
- sofobuvir (polymerase inhibitor)
