Hepatocellular Carcinoma

Question 1

Hepatocellular Carcinoma risk factors?

Answer 1

alcoholic cirrhosis,

HBV, HCV,

hemochromatosis,

Wilson disease,

α-1-antitrypsin
deficiency

hepatic carcinogens (eg, aflatoxin B1)

Question 2

Hepatocellular Carcinoma gross fx?

Answer 2

May appear as:

single mass,

multiple masses

infiltrative carcinoma;

pale and green tinted

Question 3

Hepatocellular Carcinoma histo fx?

Answer 3

Tumors:

range from cords or sheets of cells roughly resembling hepatic parenchyma
to anaplastic masses;

may invade portal veins or IVC

Question 4

Hepatocellular Carcinoma spread by?

Answer 4

hematogenous dissemination,

often to the:
lungs, 
vertebrae, 
adrenals,
brain

Question 5

Hepatocellular Carcinoma clinical signs?

Answer 5

Fever;

weight loss;

worsening hepatomegaly;

worsening or bloody
ascites;

cirrhotic symptoms

Question 6

Hepatocellular Carcinoma lab findings?

Answer 6

Elevated AFP,

leukocytosis,

anemia,

sudden elevation of ALP

Question 7

Hepatocellular Carcinoma treatment?

Answer 7

Surgical resection;

chemotherapy;

radiotherapy;

liver transplantation

Question 8

Hepatocellular Carcinoma prognosis?

Answer 8

Death often occurs within 10 months of diagnosis

Question 9

Hepatocellular Carcinoma epid?

Answer 9

most common primary malignant tumor of the liver in adults.

Question 10

What is Cholangiocarcinoma?

Answer 10

aggressive tumor arising from the intrahepatic biliary ducts

Question 11

Cholangiocarcinoma associated with?

Answer 11

Clonorchis sinensis infestation

and primary sclerosing cholangitis.

Question 12

Liver adenomas related to?

Answer 12

oral contraceptive use?

Question 13

Liver adenomas complications?

Answer 13

intraperitoneal hemorrhage

Question 14

Liver angiosarcomas related to?

Answer 14

polyvinyl chloride (Thorotrast) exposure