Viral Hepatitis

Question 1

Viral Hepatitis etio?

Answer 1

HAV and HEV are transmitted fecal-orally. HBV, HCV, HDV are blood-borne viruses

Question 2

Acute hepatitis (all viruses) gross fx?

Answer 2

enlarged, red liver (green if cholestatic)

Question 3

Acute hepatitis (all viruses) histo fx?

Answer 3

swelling of hepatocytes; 
ground-glass hepatocytes (HBV); cholestasis; 
macrophage aggregation;
bridging necrosis; 
portal tract inflammation; 
hyperplasia of Kupffer cells.

Question 4

Chronic hepatitis (HBV, HCV, HDV) gross fx?

Answer 4

cirrhotic liver with fibrous septa and irregular nodules.

Question 5

Chronic hepatitis (HBV, HCV, HDV) histo fx?

Answer 5

bridging fibrosis of the portal and periportal regions;

lymphoid aggregates.