Herpes Viridae Part 2 Flashcards
(37 cards)
What are the 4 pathotypes of Marek’s Dz?
Mild
Virulent
Very Virulent
Very Virulent +
mMDV is mostly associated with ____ MD and prevntable with ______
neural MD
turkey herpesvirus vx
Marek's Dz Etiology Hosts Distribution Transmission
Gallid herpesvirus 2
Chickens mostly but other poultry too
Worldwide
Feather follicles and dander (less infectious)
vMDV is associated with high incidence of ______ and _______ lymphomas. Disease is preventable with ________
neural and visceral
HTV, turkey herpes virus vx
vvMDV is associated with high incidence of ______ and _______ lymphomas. Viruses are oncogenic in ______ _________ chickens. Dz is preventable with _______
neural and visceral lymphomas
HVT vx chickens
bivalent vx
vv+MDV is associated with high incidence of neural and visceral lymphomas. Viruses are oncogenic in chickens ________
vx with bivalent vx
What are the genetically susceptible and resistant haplotypes of MHC II of chickens in regards to Marek’s Dz?
B19- susceptable
B21- resistant
What are the clinical signs in Marek’s Dz
Neurolymphamatosis
Visceral lymphomatosis
Ocular lymphomatosis
Cutaneous lymphomatosis
In Marek’s Dz, which is reportable, what is the most protective commercial vx available?
CVI988/Rispens
Inclusion Body Rhinitis Etiology Host Distribution Transmission
Porcine Herpesvirus2/Porcine cytomeglovirus
Pigs, 2-10 wks old. Severe if less than 3 wks old.
Worldwide
Inhalation and Transplacental
Pathogenesis of Inclusion Body Rhinitis
Widespread petechiae and edema
Most common in thoracic cavity and sq tissues
Clinical signs associated with Inclusion Body Rhinitis
Pigs less than 3 wks- mucopurulent rhinitis, violent sneezing and resp distress
Neonatal pigs appear weak, anemic, stunted
Can cause mummification or still births
Subclinical in older adults
Malignant Catarrhal Fever
Host
Etiology
Cattle and Wild Ruminants
Alcephaline herpesvirus-1 (Wildebeast associated MCF)
Ovine herpesvirus-2 (Sheep associated MCF)
Wildebeast associated MCF
transmitted from cattle to wildebeast
occurs in most african countries
doesn’t cause dz in Wildebeast/principal host
is epizootic and seasonal
Sheep associated MCF
world wide
transmitted from sheep (or goats) to cattle
occurs year round in cattle
sporadic, occasional outbreaks
How is Wildebeast associated MCF transferred to cattle?
It’s present in the nasal and occular secretions of young wildebeast, cows eat it from contaminated pasture or direct/close contact, inhalation of aerosol, contact with calving wildebeast. Rarely transmitted from adults.
How is MCF transmitted from Sheep to Cattle?
Unknown, maybe inhalation or ingestion
Clinical Signs in MCF
Peracute- sudden death
Head and eye- majority
Alimentary/Intestinal- diarrhea, more common in sheep MCF
Mild form- innoculated animals
In what virus would you find Zebra striping of the bovine colon?
MCF
Hemorrhagic Dz of Puppies
Etiology
Host
Transmission neonates and older dogs
Canine herpes virus 1
Dogs and wild canidae
neonates- contact w/ oral/nasal/vaginal secretions, in utero, from passage through birth canal
older dogs- venereal transmission, contact w/ infected puppies
At what temp does CHV-1 replicate at?
33C
Found in outer genital and upper respiratory tracts
Clinical signs of Hemorrhagic Dz of puppies
Hemorrhages in multiple organs
painful crying, abdominal pain, anorexia, dsypnea, no elevation in body temperature
If survive, develop persistant neruo signs like ataxia and blindness
Hemorrhagic Dz of Puppies
Adult genital infection
Adult Respiratory Infection
Ocular Infection
Genital- generally asymptomatic, in utero can cause abortion/mummies
Respiratory- older dogs, rhinitis and pharyngitis
Ocular- conjunctivitis
Hemorrhagic Dz of Puppies
Focal areas of necrosis
Intranuclear inclusion bodies
FAT serology
