Herpesvirus Flashcards
(88 cards)
Herpesviridae morphology
Enveloped, spherical to pleomorphic
icosahedral capsid, T=16
Herpesvirus capsid contains a globular material called ___
Tegument
Herpesvirus genome
monopartite, linear, double-stranded DNA genome
Herpes virus replication occurs in ___
the nucleus
T or F
some herpesviruses are oncogenic
True
Herpesvirus inclusion bodies
Type A Cowdry bodies, eosinophilic intranuclear , composed of nucleic acid and protein
herpesvirus facilitates cell-to-cell fusion that spread the infection and avoids the immune system
Syncytium
Herpesvirus capsid contains a globular material called ___
Tegument
Bovine Herpesvirus belongs to subfamily ____
Alpha herpesvirus
3 subtypes of bovine herpesvirus
Respiratory
Genital
Encephalitic
Bovine herpesvirus: transmission
Respiratory disease and conjunctivitis from droplets
Genital disease from coitus
Bovine herpesvirus: Pathogenesis
1st- cell-asso. viremia
focal epithelial cell necrosis, inclusions may be in nuclei
intense inflammatory response
life long latency in Trigeminal n. (resp.) and Sciatic n. (genital)
Bovine herpesvirus: Clinical signs - Respiratory
red nose, necrotic rhinitis, dust pneumonia
mucopurulent nasal discharge, death maybe by 2nd infection
conjunctivits, abortion, systemic infected calves
Bovine herpesvirus: Clinical signs - genital
Infectious pustular vaginitis (IPV)
swollen vulva, mild discharge, inflamed pustules on penis
Bovine herpesvirus: control
modified live vaccines
combination or multivalent vaccines
Bovine herpesvirus 2 causes ___
Bovine ulcerative mammillitis
Pseudo-lumpy skin disease
BUM: hosts
cows, usually in 2 weeks of calving
BUM: transmission
direct contact and fomites by damage to skin
Mechanical by arthropods
BUM: Clinical signs
swollen, painful teats, bluish skin and exudates serum to ulcers
reduce milk yield, mastitis
Pseudo-lumpy skin disease: transmission
Mechanically by arthropods
Pseudo-lumpy skin disease: Clinical signs
mild fever, skin nodules with flat surface and depressed center
Porcine herpesvirus 1 causes ___
Pseudorabies (Aujeszky disease, Mad itch)
Pseudorabies: transmission
recovered pigs are primary reservoir (also rats)
shed in saliva, nasal discharge, and milk
Pseudorabies: Pathogenesis
primary- upper respiratory tract, spreads by lymphatics
to CNS (pons and medulla)
-ganglioneuritis, nonsuppurative meningoencephalitis, perivascular cuffing