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Flashcards in high yield Deck (50)
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1
Q

coagulase on ?

A

S. aureus

2
Q

TSST uses ___?

A

super antigens

3
Q

Glycocalyx on?

A

Staph epidermis

4
Q

Strep pyogen has _ protein

A

M

5
Q

M protein on ?

A

Strep - pryogenes

6
Q

Who has antiphagocytic polysaccarhides capsule

A

strep pneumoniae

7
Q

3 main causes of endocaridits bugs

A

S. aureus, Coagulase negative staph (so basically all staph)

Strep viridan

8
Q

Rheumatic heart disease from which bug?

A

Strep pygoens (strep)

9
Q

Dextran made by ?

A

viridans streptococci

10
Q

Classify N. gonorrhoeae

A

Gram neg, diplo-cocci

11
Q

Drug enter CSF

A
cephalosporin 3/4
Metronidzaole
Chloroamphenicol
Sulfoamides/trimethoprim
Rifampin
12
Q

Drug enter CSF with inflammation

A

vanco
penicillin
ciprofloxacin
Tetracycline

13
Q

Drug enter CSF Poor

A

Aminoglycosides
Cephalosporin 1/2
erythromycin
clindamycin

14
Q

Drugs fetus/pregnancy

A

aminoglycosides, variconazole, metronidazole, chloroamphenicol, tetracycline, fluoroquinolone

15
Q

Bone accumulation

A

Clindamycin

16
Q

accumulation lungs

A

macrolides

17
Q

accumulation peridonitis/acne

A

tetracyclines

18
Q

UTI accumulation

A

Nitrofurantonin

19
Q

accumulation 8th nerve/renal

A

aminoglycosides

20
Q

accumulation in bone/teeth bad

A

tetracycline in kids

21
Q

B-ALL markers

A

CD19, CD22, CD79a

NO CD20/surface IgX (not mature)

22
Q

T-ALL markers

A

CD2, 3, 7
CD4/8
CD99, CD1a

23
Q

ALL general markers

A

CD34, TdT

HLA-DR

24
Q

B-all diseases genes/prognosis/age

A

BCR-ABL(9:22) worst - adults
MLL t11q23 poor - baby
ETV6-RUNX1 (t12;21) - good - children

25
Q

T-ALL prognosis, patient profile

A

Good (better young)
Males
Mediastinal mass

26
Q

AML markers

A

CD34, HLADR, CD38 (immature)

CD117 (Ckit), MPO - myeloid markers

27
Q

CD 34 =?

A

immature

28
Q

CD117

A

myeloid

29
Q

MPO

A

myeloid

30
Q

TdT

A

lymphoid

31
Q

Name AML disesases (6)

A
MLL 11q23 - poor
RUNX1-RUNX1T1 (t8:21) good - young
RBM15-MKL1 t(1:22) infant good
PML-RARA t(15;17( APL) - good 
2 t-aml - therapy
32
Q

APL 2 things to know

A

treat with ATRA and risk for DIC

33
Q

Aklyating agent –> MDS time

A

2-8 years; MDS –> AML

chr 5/7

34
Q

Topo agent –> effect

A

1-2 yr; MLL 11q23

35
Q

Three indicators of AML

A

FLT3-ITD
NPM1
CEBPA

36
Q

MDS types

A

RCUD
RCMD
RAEB1
RAEB2

37
Q

SLL/CLL markers

A

CD23

SMudge cell

38
Q

Follicular lymphoma markers

A

BCL2 - prevents apoptosis
(CD19, 20, 10, BCL6)
t(14:18)

39
Q

Mantle Cell lymphoma

A

t(11:14)
BCL1 - G1->S cell cycle
(CD5, 10, 20)

40
Q

Burkitt’s lymphoma describe

A

t(8:14)
Starry sky appearence
MYC

41
Q

Plasma cell - multiple myeloma signs

A

CRAB: high ca, renal insuff, anemia, bone lesion

M protein spike

42
Q

CHL

A

RS cells
CD30 CD 15
Nodular sclerosis - broad collagen bands

43
Q

Immunopathology types 1-4 basics

A

1 - allergies - IgE
2 - B cell - anitbody to self
3 - C complement
4 - Delayed/Tcell

44
Q

SCID affects

A

T and B

45
Q

Bruton’s X linked affects

A

B

46
Q

affects X linked hyperIGM

A

class switch

47
Q

CVID affects

A

no Ab

48
Q

affects Digeorge

A
absent T (stroma cells)
CATCH22- cardiac, ab face, thymic aplasia, celft palate, hypocal, chr 22
49
Q

lacunar cells in

A

nodular sclerosis - CHL

50
Q

CHL symptoms

A

fever, night sweats, painless lymphadenopathy, nephrotic syndrom/hypercalcemia