Higher Cortical Flashcards

(89 cards)

1
Q

Describe the role of the cerebral cortex in the brain.

A

The cerebral cortex acts as the ‘executive suite’ of the brain, responsible for conscious awareness, sensory perception, voluntary motor initiation, communication, memory storage, and understanding.

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2
Q

Explain the composition of the cerebral cortex.

A

The cerebral cortex is a thin layer (2–4 mm) of gray matter composed of neuron cell bodies, dendrites, glial cells, and blood vessels, but it does not contain axons.

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3
Q

How much of the total brain mass does the cerebral cortex constitute?

A

The cerebral cortex constitutes about 40% of the total brain mass.

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4
Q

Define the three types of functional areas found in the cerebral cortex.

A

The three types of functional areas in the cerebral cortex are motor areas (control voluntary movement), sensory areas (conscious awareness of sensation), and association areas (integrate diverse information).

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4
Q

Explain the concept of lateralization in the cerebral cortex.

A

Lateralization refers to the specialization of cortical function that can occur in only one hemisphere of the brain, with each hemisphere concerned with the contralateral (opposite) side of the body.

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5
Q

Describe the location and function of the primary motor cortex.

A

The primary motor cortex is located in the precentral gyrus of the frontal lobe and is responsible for the conscious control of precise, skilled, skeletal muscle movements.

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6
Q

What is the significance of pyramidal cells in the primary motor cortex?

A

Pyramidal cells are large neurons in the primary motor cortex that allow for conscious control of precise, skilled movements.

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7
Q

Explain the concept of somatotopy in the primary motor cortex.

A

Somatotopy refers to the mapping of all muscles of the body to specific areas on the primary motor cortex, allowing for organized control of movement.

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8
Q

What is the motor homunculus?

A

The motor homunculus is an upside-down caricature that represents the contralateral motor innervation of different body regions in the primary motor cortex.

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9
Q

Describe the areas of the cortex involved in conscious awareness of sensation.

A

The areas involved in conscious awareness of sensation include the primary somatosensory cortex, somatosensory association cortex, visual areas, auditory areas, vestibular cortex, olfactory cortex, gustatory cortex, and visceral sensory area.

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10
Q

Where is the primary somatosensory cortex located and what is its function?

A

The primary somatosensory cortex is located in the postcentral gyrus of the parietal lobe and is responsible for receiving general sensory information from the skin and proprioceptors.

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11
Q

What is spatial discrimination in the context of the somatosensory cortex?

A

Spatial discrimination is the ability to identify the specific body region being stimulated, which is a function of the primary somatosensory cortex.

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12
Q

Explain the role of the visual association area in the cerebral cortex.

A

The visual association area surrounds the primary visual cortex and uses past visual experiences to interpret visual stimuli, such as color, form, or movement.

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13
Q

Describe the location and function of the primary auditory cortex.

A

The primary auditory cortex is located on the superior margin of the temporal lobes and interprets information from the inner ear regarding pitch, loudness, and location.

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14
Q

What is the function of the auditory association area?

A

The auditory association area, located posterior to the primary auditory cortex, stores memories of sounds and allows for the perception of sound stimuli.

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15
Q

Where is the gustatory cortex located and what does it perceive?

A

The gustatory cortex is located in the insula, just deep to the temporal lobe, and is involved in the perception of taste.

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16
Q

What is the function of the olfactory cortex?

A

The olfactory cortex is located on the medial aspect of the temporal lobe and is responsible for the perception of smell.

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17
Q

Describe the role of the piriform lobes in the brain.

A

The piriform lobes are part of the primitive rhinencephalon and are involved in the conscious awareness of odor.

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18
Q

Explain the function of the cerebral cortex’s multimodal association areas.

A

Multimodal association areas receive inputs from multiple sensory areas, give meaning to the information, store it in memory, tie it to previous experiences, and help decide on actions.

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19
Q

Define the anterior association area of the cerebral cortex.

A

The anterior association area, also known as the prefrontal cortex, is involved with intellect, cognition, recall, personality, and contains working memory for abstract ideas, judgment, reasoning, persistence, and planning.

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20
Q

How does the development of the anterior association area depend on external factors?

A

The development of the anterior association area depends on feedback from the social environment.

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21
Q

Describe the function of the posterior association area in the cerebral cortex.

A

The posterior association area, located in the temporal, parietal, and occipital lobes, plays a role in recognizing patterns and faces, localizing us in space, and understanding written and spoken language.

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22
Q

Explain the significance of the limbic association area.

A

The limbic association area, part of the limbic system, involves structures like the cingulate gyrus and hippocampus, providing emotional impact that makes scenes important and helps establish memories.

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23
Q

What is functional neuroimaging and its relevance to the cerebral cortex?

A

Functional neuroimaging, such as PET and MRI, shows that specific motor and sensory functions are located in discrete cortical areas called domains, while higher functions are spread over many areas.

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24
How are brain waves recorded and what do they reflect?
Brain waves are patterns of neuronal electrical activity recorded by an electroencephalogram (EEG), reflecting the electrical activity of higher mental functions.
25
Describe the use of EEG in clinical settings.
EEG is used for diagnosing epilepsy and sleep disorders, localizing lesions, tumors, infarcts, infections, and abscesses, and determining brain death.
26
Explain how EEG measures electrical activity in the brain.
EEG measures electrical potential differences between various cortical areas, capturing patterns of neuronal electrical activity generated by synaptic activity in the cortex.
27
What factors can influence an individual's brain wave patterns?
An individual's brain wave patterns can change with age, sensory stimuli, brain disease, and the chemical state of the body.
28
Define the four classes of brain waves based on frequency in Hertz (Hz).
The four classes of brain waves are: Alpha waves (8–13 Hz), Beta waves (14–30 Hz), Theta waves (4–7 Hz), and Delta waves (below 4 Hz).
29
Describe alpha waves and their significance.
Alpha waves (8–13 Hz) are regular, rhythmic, low-amplitude, synchronous waves indicating an 'idling' brain.
30
What characterizes beta waves in brain activity?
Beta waves (14–30 Hz) are rhythmic, less regular waves that occur when a person is mentally alert.
31
Explain the characteristics of theta waves.
Theta waves (4–7 Hz) are more irregular and are associated with light sleep or relaxation.
32
Describe delta waves and their significance in sleep and brain health.
Delta waves are high-amplitude brain waves (4 Hz or less) that occur during deep sleep and when the reticular activating system is suppressed, such as during anesthesia. In awake adults, the presence of delta waves may indicate brain damage.
33
Explain the role of Broca's area in language processing.
Broca's area is involved in speech production. Patients with lesions in this area can understand words but are unable to speak.
34
Define Wernicke's area and its function in language comprehension.
Wernicke's area is responsible for understanding spoken and written words. Patients with lesions in this area can speak but produce nonsensical words.
35
How does the language implementation system function in the brain?
The language implementation system involves the association cortex of the left hemisphere, with Broca's area for speech production and Wernicke's area for language comprehension.
36
List the different types of memory and provide examples for each.
The different types of memory include: 1. Declarative (fact) memory - names, faces, words, dates; 2. Procedural (skills) memory - playing piano; 3. Motor memory - riding a bike; 4. Emotional memory - experiences linked to emotions, like heart pounding when hearing a rattlesnake.
37
Explain the two stages of declarative memory storage.
The two stages of declarative memory storage are: 1. Short-term memory (STM or working memory) - temporary holding of information, limited to seven or eight pieces; 2. Long-term memory (LTM) - has limitless capacity.
38
What factors affect the transfer of information from short-term memory to long-term memory?
Factors affecting the transfer from STM to LTM include emotional state (best when alert or motivated), rehearsal (repetition and practice), and association (tying new information with old memories).
39
Describe the process of memory consolidation.
Memory consolidation involves fitting new facts into categories already stored in the cerebral cortex, with the hippocampus, temporal cortical areas, thalamus, and prefrontal cortex playing key roles.
40
What are the effects of damage to the hippocampus on memory?
Damage to the hippocampus or surrounding temporal lobe structures can result in slight memory loss, while bilateral destruction can cause widespread amnesia.
41
Differentiate between anterograde and retrograde amnesia.
Anterograde amnesia involves the inability to associate new inputs with old memories, leading to a focus on the present, while retrograde amnesia is the loss of memories formed in the distant past.
42
Explain the components of consciousness.
Consciousness involves the perception of sensation, voluntary initiation and control of movement, and capabilities associated with higher mental processing such as memory, logic, and judgment.
43
Describe the continuum of consciousness as defined clinically.
The continuum of consciousness includes alertness, drowsiness (lethargy), stupor, and coma, grading behavior in response to stimuli.
44
Explain the current suppositions on consciousness.
Consciousness involves simultaneous activity of large cortical areas, is superimposed on other types of neural activities, and is holistic and interconnected.
45
How does loss of consciousness signal brain function impairment?
Except during sleep, loss of consciousness indicates that brain function is impaired.
46
Define fainting or syncope.
Fainting or syncope is a brief loss of consciousness, most often due to inadequate cerebral blood flow, low blood pressure, or ischemia.
47
What characterizes a coma?
A coma is an extended period of unconsciousness that is not the same as deep sleep, with lowered oxygen consumption.
48
Describe brain death.
Brain death is defined as irreversible coma, raising ethical and legal issues regarding whether a person is dead or alive.
49
Explain what occurs during an epileptic seizure.
An epileptic seizure involves a torrent of electrical discharges by groups of brain neurons, preventing other messages from getting through.
50
How common is epilepsy and what are its associations?
Epilepsy occurs in 1 of 100 people and is not associated with intellectual impairments.
51
What factors can contribute to epilepsy?
Genetic factors, brain injuries, stroke, infections, or tumors can all contribute to the occurrence of epilepsy.
52
Define absence seizures.
Absence seizures, formerly known as petit mal, are mild seizures where the victim's expression goes blank for a few seconds, typically disappearing by age 10.
53
Describe tonic-clonic seizures.
Tonic-clonic seizures, formerly grand mal, are severe seizures lasting a few minutes, characterized by loss of consciousness, intense convulsions, and potential injury.
54
What is an aura in the context of seizures?
An aura is a sensory hallucination that may precede a seizure.
55
How is epilepsy controlled?
Control of epilepsy includes the use of anticonvulsive drugs and may involve vagus nerve or deep brain stimulator implantations.
56
Define sleep in terms of consciousness.
Sleep is a state of partial unconsciousness from which a person can be aroused by stimulation.
57
Explain the types of sleep based on EEG patterns.
There are two major types of sleep: non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep.
58
Describe the stages of non-REM sleep.
In the first 30-45 minutes of sleep, a person passes through the first two stages (N1 and N2) of non-REM sleep before moving into stage 3, known as slow-wave sleep.
59
What physiological changes occur during slow-wave sleep?
During slow-wave sleep, the frequency of brain waves declines, amplitude increases, and EEG, blood pressure, and heart rate decrease.
60
What happens during REM sleep?
During REM sleep, which begins about 90 minutes into the sleep cycle, there is temporary paralysis except for rapid eye movements, and heart rate, respiratory rate, and blood pressure increase.
61
How is sleep regulated in the body?
Sleep is regulated by the suprachiasmatic nucleus and preoptic nucleus of the hypothalamus, which control the timing of the sleep cycle.
62
What role do orexins play in sleep regulation?
Orexins are hypothalamic chemicals that help the cortex to wake up, playing a role in regulating sleep.
63
Explain the importance of sleep for memory.
During sleep, new memories are consolidated, and memories that are no longer accessed are discarded.
64
What restorative functions occur during non-REM sleep?
During non-REM sleep, cerebrospinal fluid sweeps through the brain, aiding in the removal of waste products, including those associated with Alzheimer's disease.
65
What happens when a person is deprived of sleep?
When deprived of sleep, a person spends more time in REM and slow-wave sleep in the next sleep episode to catch up.
66
Define narcolepsy.
Narcolepsy is a sleep disorder characterized by abrupt lapses into sleep from an awake state.
67
What is the role of orexins in narcolepsy?
In narcolepsy, orexins, which are wake-up chemicals, are likely destroyed by the patient's immune system.
68
Describe orexin replacement as a possible treatment.
Orexin replacement may be considered as a treatment for conditions like insomnia, which is characterized by a chronic inability to obtain the necessary amount or quality of sleep.
69
Explain the potential causes of insomnia.
Insomnia can be caused by factors such as depression, anxiety, overuse of caffeine, and excessive use of computers or cell phones close to bedtime.
70
How can insomnia be treated in relation to orexin?
Insomnia may be treated by blocking the action of orexin, which is involved in regulating wakefulness.
71
Define concussion in the context of traumatic brain injuries.
A concussion is a temporary alteration in brain function resulting from a traumatic brain injury.
72
What is a contusion and how does it differ from a concussion?
A contusion is a type of traumatic brain injury that results in permanent damage, unlike a concussion which is temporary.
73
Explain the risks associated with subdural or subarachnoid hemorrhage.
Subdural or subarachnoid hemorrhage can create pressure from blood that may force the brain stem through the foramen magnum, potentially resulting in death.
74
Describe cerebral edema and its association with traumatic head injury.
Cerebral edema refers to the swelling of the brain that is associated with traumatic head injuries.
75
What are cerebrovascular accidents (CVAs) commonly known as?
Cerebrovascular accidents (CVAs) are commonly known as strokes.
76
Define ischemia and its effects on brain tissue.
Ischemia is a condition where tissue is deprived of blood supply, leading to the death of brain tissue.
77
How can ischemia occur in the brain?
Ischemia can occur due to the blockage of a cerebral artery by a blood clot.
78
What are the potential outcomes of ischemia in the brain?
Ischemia can result in hemiplegia (paralysis on one side) or sensory and speech deficits.
79
Explain transient ischemic attacks (TIAs).
Transient ischemic attacks (TIAs) are temporary episodes of reversible cerebral ischemia.
80
Describe Alzheimer's disease and its impact on the brain.
Alzheimer's disease is a progressive degenerative disease of the brain that results in dementia, characterized by memory loss, disorientation, and eventual language loss.
81
What causes Alzheimer's disease at the cellular level?
Alzheimer's disease is caused by the misfolding of proteins that clump together, forming plaques of beta-amyloid peptides and neurofibrillary tangles inside neurons.
82
How does Alzheimer's disease affect brain function over time?
As brain cells die in Alzheimer's disease, functions are lost, and the brain shrinks.
83
What treatments are available for Alzheimer's disease?
Treatment for Alzheimer's disease includes drugs that inhibit the breakdown of acetylcholine, block toxic effects of excess glutamate, or stimulate the destruction of beta-amyloid.
84
Define Parkinson's disease and its primary neurological impact.
Parkinson's disease is characterized by the degeneration of dopamine-releasing neurons in the substantia nigra, leading to overactivity in basal nuclei and resulting in tremors at rest.
85
What are some theories regarding the cause of Parkinson's disease?
Theories regarding the cause of Parkinson's disease include mitochondrial abnormalities and protein degradation pathways.
86
What treatments are available for managing Parkinson's disease symptoms?
Treatment for Parkinson's disease includes L-dopa (a dopamine precursor), deep brain stimulation with electrodes, and implanting stem cells.
87
Describe Huntington's disease and its genetic basis.
Huntington's disease is a fatal hereditary disorder caused by the accumulation of the protein huntingtin in brain cells.
88
Explain the significance of a knee-jerk reflex test.
A knee-jerk reflex test can indicate potential issues such as intracranial hemorrhage, multiple sclerosis, or hydrocephalus based on abnormal responses.