Flashcards in Histology 1 - Cardiovascular Deck (14):
Obstruction of the blood supply to an organ or region of tissue, causing local death
A small, localised area of dead tissue resulting from a failure of blood supply
In what part of the artery does an atheromatous plaque develop?
Forms in the tunica intima of the artery
Where (in relation to the lumen) is the fibrous cap located in the artery?
The fibrous cap is located towards the lumen of the artery
What is the fibrous cap composed of?
Composed of smooth muscle cells, macrophages, foam cell, lymphocytes, collagen, elastin, proteoglycans and neurovascularisation
What is the 'necrotic centre'?
This is the part of the atheroma towards the artery wall
What is the necrotic centre composed of ?
Cell debris, cholesterol crystals, foam cells, calcium
What does dark staining myocardium indicate?
Dark staining indicates acute inflammation and infarcted muscle
How does staining of the myocardium change with an increased level of infarction?
As the muscle infarct worsens, the infarcted area becomes more an more condensed and so appears darker and darker on a stain
The stain also appears less and less pink and starts to appear more white as a collagen mesh starts to form
There is also an increased level of infiltration of inflammatory cells, neutrophils
What is rheumatic fever?
This is an inflammatory disease that can involve the heart, joints, skin and the brain
Typically develops 2-4 weeks following a streptococcal throat infection
What are 'Aschoff bodies' and how do they occur?
These are nodules that are found in the hearts of individuals with rheumatic fever - located in the myocardium of the heart
These are characteristic of rheumatic fever
Results from inflammation of the heart muscle
What do Aschoff bodies look like on the heart?
Appear as small red bumps on the heart e.g. around the mitral valve
What can chronic damage from rheumatic fever and inflammation result in in a valve?
Can lead to e.g. rheumatic mitral stenosis
Fusion of commisures and fusion and shortening of the chordae tendinae