Flashcards in Histology Of The Urinary Tract Deck (21)
What is found at the vascular and urinary poles of the renal corpuscle?
Vascular pole - afferent/efferent arterioles and glomerulus
Urinary pole - Bowman's capsule
How does the Bowman's capsule develop?
Renal tubule is derived from the ureteric bud. Envelopes the growing glomerulus, resulting in a double layers cover - the Bowman's capsule.
Function of the renal corpuscle?
Produce an ultrafiltrate of the plasma
Epithelium of the parietal layer of Bowman's capsule?
What is the filtration barrier made up of?
Visceral layer of Bowman's capsule
Fenestrated capillary endothelium with podocytes invested in it
What role does the parietal layer of Bowman's capsule play in filtration?
Forms a funnel to collect the ultrafiltrate to drain into PCT
Epithelium of the proximal convoluted tubule?
Simple cuboidal with a brush border
What are the four parts of the loop of Henle?
Thin descending limb*
Thin ascending limb
Thick ascending limb*
*only parts you need to think about for function
What is the epithelium of the thin descending limb? Significance of this?
Simple squamous - means there is no active transport
How do you differentiate between the thin descending limb and a capillary on a sample?
Capillary will have red blood cells
Epithelium of the thick ascending limb? Significance of this?
Can do active transport
How can you tell the difference between the thick ascending limb and PCT?
PCT has a brush border
Epithelium of the distal convoluted tubule?
How can you tell the difference between PCT and DCT?
DCT has no brush border and a larger lumen
What is the juxtaglomerular apparatus?
The area where the DCT a makes contact with the parent glomerulus
What is the juxtaglomerular apparatus made up of?
Macula densa - dense staining region
Juxtaglomerular cells - cells of the afferent arteriole
Extraglomerular mesangial cells - occupy space between glomerulus and tubular system
Epithelium of collecting duct?
How can you tell the difference between the CD and ascending limb?
CD has a larger lumen that is more irregular than circular
Describe the renal pyramid
Where progressively larger ducts merge and empty at the renal papilla to form a pyramid shape.
Describe the histology of the ureter
Two layers of smooth muscle - a third appears in the lower third of the ureter
Lined by transitionary epithelium/urothelium