Histopath - Systemic, Endo, CTD, Bone & Soft tissue Flashcards
AA Amyloid type
Serum amyloid A (acute phase protein synthesised by liver)
Long standing inflammatory disease e.g., Crohn’s, Rh arthritis
Al amyloid type
Derived from light chains
Seen in Multiple myeloma, B cell lymphoma
Hallmark feature of PID
Salpingitis
Classical of Cervical intraepithelial neoplasia
CIN 1 = lower third
CIN 2 = lower two thirds
CIN 3 = entire thickness
Most common cervical cancer type
Squamous cell carcinoma
high risk (of cancer) HPV strains
16, 18, (33)
Which HPV viral proteins involved in cancer pathogenesis
E6 - binds p53
E7 - binds Retinoblastoma (Rb)
Most common uterine tumour
Leiomyoma (fibroid)
Staging of (endometrioid) uterine cancer
Stage 1A = <50% myometrial invasion
Stage 1B = >50% myometrial invasion
Stage 2 = invades cervical stroma
Stage 3A = invades serosa of corpus uteri and/or andexa
3B = vaginal and/or parametrial
3C1 = pelvic LN
3C2 = para-aortic LN
Stage 4A = bladder and/or bowel
Stage 4B = distant mets (intra-abdominal and/or inguinal lymph nodes)
Importance of POLE mutation in endometrial cancer?
Better prognosis
tumours often appear high grade histologically
What uterine cancers respond to Anti PD-1 mono therapy
EEC with POLE mutation
MSI tumour groups
Most common benign ovarian tumour
Serous cystadenoma
Syndromes that pre-dispose to ovarian sex cord stromal tumours
DICER 1 syndrome
Peutz-Jeghers syndrome
Most common renal cell carcinoma type
Clear cell renal cell carcinoma (70%)
Which renal disease has Abs against phospholipase A2
Membranous glomerulonephritis
