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ANTIFÚNGICOS > Histoplasmosis. > Flashcards

Histoplasmosis. Flashcards

1
Q

ITRACONAZOL.

A

Inhibidores de 14-α desmetilasa (síntesis de ergosterol)

AZOL = desmetilasa

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2
Q

ANFOTERICINA B.

A

ionóforo: se une al ergosterol para formar canales/poros que incrementan la permeabilidad de la membrana

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3
Q

histoplasmosis

A
  • itraconazol
  • anfotericina B

” para contar la HISTOria (HISTOplasmosis) TRAje (iTRAconazol) una ANFora (ANFotericina B)”

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4
Q

Inhibidores de 14-α desmetilasa

A

ITRACONAZOL

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5
Q

Formación de canales/poros que incrementan la permeabilidad de la membrana

A

ANFOTERICINA B.

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6
Q

EA anfotericina B

A
  • Toxicidad renal (tubulo distal)
  • Hematológicos: anemia (↓EPO)
  • hipokalemia y cardiomiotoxicidad
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7
Q

distribución de anfotericina B

A

atraviesa la BHE

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8
Q

resistencia a anfotericina B

A

disminución de la expresión de ergosterol u ocultamiento

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ANTIFÚNGICOS (3 decks)

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