HIV Flashcards
Normal CD4 T cell count
800-1200 cells/uL
Stage 2 HIV TC4 T count
<500 cells/uL
Stage 3 HIV CD4 T count
<200 cells/uL
When is a pt’s HIV undetectable/untransmissable?
When HIV RNA levels are <200 copies/mL
When someone is being treated for HIV, what should happen to the number of copies and the number of CD4 T cells?
The number of copies should go down
CD4 number should go up
Symptoms of Stage 1 HIV
Fever
Swollen lymph nodes
Sore throat
Headache
Malaise
Nausea
Muscle and joint pain
Diarrhea
Diffuse rash
Antiretroviral drugs that block viral entry into cells
Fusion inhibitors antagonists
CCR5
Drugs that inhibit enzymes required for HIVs
Reverse transcriptase inhibitors
(NRTIs & NNRTIs)
Integrase strand transfer inhibitors
Protease inhibitors
Example of cART
BIKTARVY
Which drugs make up BIKTARVY?
Bictegravir (BIC)
Tenofovir alafenamide (TAF)
Emtricitabine (FTC)
Side effects of cART
Decreased WBC counts
Low platelet counts
Anemia
Altered liver & kidney function
Depression
Drug/alcohol use
How is AIDS diagnosed?
CD4T cells <200
Diagnosis of opportunistic infections
Diagnosis of AIDS-related malignancy
Clusters of symptoms you should look for when assessing for HIV
Opportunistic infections
Malignancies
Endocrine complications
Cardiovascular complications
N/V, diarrhea, fatigue, pain, peripheral neuropathy
Examples of opportunistic infections
Viral infections:
Herpesvirus family:
- cytomegalovirus retinitis
- HSV
- Varicella Zoster Virus (shingles)
- Epistein-Barr virus
Oral hairy leukoplakia
Oral thrush or vaginal candida
*Pneumocystis Jiroveci Pneumonia
Examples of opportunistic malignancies
Kaposi’s Sarcoma
NHL B cell
Cervical cancer
