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NAPLEX Prep > HIV > Flashcards

HIV Flashcards

(46 cards)

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1
Q

Dolutegravir

A

Tivicay

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2
Q

Tivicay

A

Dolutegravir

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3
Q

Dolutegravir/lamivudine

A

Dovato

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4
Q

Dovato

A

doluteg/lamivudine

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5
Q

dolutegravir/lamivudine/abacavir

A

triumeq

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6
Q

triumeq

A

dolutegravir/lamivudine/abacavir

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7
Q

dolutegravir/emt/TAF

A

Biktarvy

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8
Q

biktarvy

A

dolut/emt/TAF

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9
Q

emt/TDF

A

Truvada

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10
Q

truvada

A

emt/TDF

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11
Q

emt/TDF

A

truvada

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12
Q

descovy

A

emt/TAF

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13
Q

emt/TAF

A

descovy

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14
Q

rilpivirine/emt/TDF

A

Complera *w food

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15
Q

Complera *w food

A

rilpivirine/emt/TDF

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16
Q

rilpivirine/emt/TAF

A

odefesy *w food

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17
Q

odefesy

A

rilpivirine/emt/TAF

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18
Q

abacavir/lamivudine

A

Epzicom

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19
Q

What are the types of based ART regimens that are COMPLETE regimens

Study These Flashcards
A

INSTI based
NNRTI based
PI based

20
Q

NRTIs
pneumonic for drugs
ADE of all
Pearls

Study These Flashcards
A

LATTE
Lamivudine (LAM)
Abacavir
TDF
TAF
Emtracitibine

ADE all: lactic acidosis, hepatomegaly with steatosis, NVD, HA, inc LFTs

BBW: SCREEN ALL PATIENTS FOR HEP C AND HEP B FIRST
ABACAVIR: Screen for HLA-B*5701 allele

21
Q

Lamivudine
Brand name
MOA
in which regimens

Study These Flashcards
A

Epivir
NRTI
in QD and BID regimens

22
Q

Abacavir
MOA
What is special about abacavir

Study These Flashcards
A

NRTI
Screen for HLA-B*5701 allele
BBW for hypersensitivity rxn, if occurs patient must carry card saying abacavir HSRxn

23
Q

Emtracitibine
MOA
ADE

Study These Flashcards
A

NRTI
hyperpigmentation of palms and soles of feet

24
Q

TDF and TAF
adverse effects of each

Study These Flashcards
A

TDF (D for Dumpy)
- renal impairment, acute renal failure and fanconi
- dec dose in renal imp (CI CrCl <50)
- must avoid nephrotoxins (NSAIDS, AGs)
- dec MBD: dexa scans, CA and Vit D!

TAF
- hyperlipidemia

these ADE are not mutually exclusive, are just more predominant in one or other

25
NNRTIs "-virine" pneumonic for drugs what regimens are these part of
REDEN Rilpivirine Efavirenz Doravirine Etavirine Neviripine NNRTI-based regimens with NNRTI +2NRTIs
26
why are there no NRTI based regimens
NRTIs have low barrier to resistance
27
rilpivirine MOA regimens part of Pearls
NNRTI NNRTI-based regimens with 2 NRTIs RPV/EMT/TDF = Complera RPV/EMT/TAF = Odefesy take with FOOD and WATER (NO PROTEIN DRINKS) CI with PPI, H2RA, antacids Do not use if viral load >100,000 or CD4 <200 (high failure rate) ADE: depression, inc SCr
28
efavirenz MOA regimens part of Pearls
NNRTI Part of NNRTI-based regimens Atripla (D/C'd) and Symfilo (EFA/LAM/TDF) take on EMPTY STOMACH qhs ADE: CNS tox (sleep) so take at night, food would inc F but inc CNS tox depression, suicidal thoughts
29
INSTIs drugs ADE
dolutegravir, cabotegravir, elvitegravir, raltegravir ADE: HA, insomnia, D, weight gain, depression, suicidal ideation exacerbation of preexisting psych conditions
30
Protease inhibitors (-navir) ADE all DDI/do not use with
ADE: inc LDL, inc TG, inc body fat, inc BG, insulin resistance. abdominal adiposity --> metabolic syndrome inc LFTs, hepatitis SJS/TEN, angioedema, bronchospasm D/N inc CVD risk ALL ARE 3A4 SUBSTRATES AND INHIBITORS DDI/do not use with alfuzosin colchicine dronaderone lovastatin, simvastatin 3A4 inducers (carbamazepine, penobarbital, rifampin, SJ Wort, phenytoin) DOACs, ticagrelor Hep C antivirals hormonal contraceptives steroids
31
atazanavir MOA ADE Pearls
PI hyperbilirubinemia needs ACDIC gut take atazanavir 2 hours before or 1 hour after for tums and 10 hours after for H2RA
32
which PIs should be used with caution in sulfa allergy
darunavir, tipranavir, fosamprenavir
33
ritonavir DDI specific
ritonavir solution contains 43% alcohol --> avoid with metronidazole 2/2 disulfiram reaction
34
why is ritonavir used as booster and not a PI
doses needed for ART are too high to tolerate and lower doses are used for boosting others
35
cobicistat MOA
booster, inhibits 3A4
36
are boosters (rilpivirine and cobicistat) taken with or without food?
with food
37
Miraviroc MOA pearls
CCR5 inhibitor need tropism test beforehand to ensure HIV strain uses CCR5 or else ineffective (CXCR4/CCR5 mixed does not qualify) CI CrCl <30 or use with 3A4 inducers or inhibitors
38
fostemsavir MOA when to use
attachment inhibitor used with other ARV in patients who are treatment experienced and not responding to current therapy
39
ibalizumab-uiyk (Troganzo IV)
post-attachment inhibitor used with other ARV in patients who are treatment experienced and not responding to current therapy
40
enfuvirtide (Fuzeon) MOA ADE
fusion inhibitor ADE: bacterial PNA, HSRxn, inj site reaction
41
opportunistic infections possible in AIDS
MAC (mycobacterium avium complex) pneumocystis jirovecii pneumo (PCP) cryptococcus neoformans histoplasmosis severe candida infections (thrush, TB)
42
Cancer thats common in AIDS
Kaposi's sarcoma
43
HIV wasting syndrome s/sx and tx options
dec appetite dec body fat dec muscle mass dronabinol, megestrol inc appetite
44
HIV in pregnancy if on tx vs tx naive
continue current treatment if naive, INSTI-based regimens with 2 NRTIs preferred (Biktarvy, Triumeq, Striblid, Genvoya) CANNOT BREASTFEED
45
PrEP when given meds preferred
before high risk activity Truvada (EMT/TDF) Descovy (EMT/TAF)
46
PEP when given preferred meds monitoring
within 72 hours after high risk activity Raltegravir (Isentress) or Dolutegravir (Tivicay) PLUS Truvada get baseline HIV Ab, repeat at 4-6 weeks, 3 months, 6 months

NAPLEX Prep (57 decks)

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