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Flashcards in HIV Deck (18):
1

What is HIV?

A retrovirus that causes AIDS (Acquired immunodeficiency virus)

2

What is the target of the HIV virus?

CD4 receptors- A glycoprotein found on the surface of a range of cells incl TH cells, dendrites, macrophages and microglial cells

3

What do CD4 Th cells do?

Recognise MHC2 APC
Activate B cells
Activate CD8
Cytokine release

4

What effect does HIV have on immune response?

Pooling of cells in lymphoid tissue

Reduced proliferation of CD4 cells

Reduced CD8 activity

Reduced antibody class switching

5

What value of CD4 count puts you at risk of opportunistic infections?

<200 cells/mm3

6

Progression of infecction from exposure?

Infection of mucosal CD4 cells (Langerhans and dendrites)

Transport to regional lymph nodes

Infection established within 3 days entry

Dissemination of virus

7

When do HIV symptoms start to appear?

2-4 weeks after infection

8

Symptoms of primary HIV infection?

Combination of:

- Fever
- Rash (Maculopapular)
- Myalgia
- Pharyngitis
- Headache/aseptic meningitis

9

Signs and symptoms of Pneumocystis pneumonia?

Insidious onset
SOB
Dry cough
Exercise desaturation

CXR interstitial infiltrates and reticulonodular markings

10

Treatment of PCP?

High dose co-trimoxazole +/- steroid

11

Other complications of HIV?

TB
Cerebral toxoplasmosis
CMV

12

Causative organism of cerebral toxoplasmosis?

Toxoplasma gondii

13

Skin infections associated with HIV?

Herpes zoster
Herpes simplex
HPV

14

What is Slim's disease?

HIV associated wasting

15

Which cancers are related to AIDS?

Kaposi Sarcoma- Vascular tumour
NH Lymphoma
Cervical

16

HIV modes of transmission?

Sexual - main
Parenteral
Mother-child

17

Which markers are used to test for HIV?

Antibody
Viral RNA
p24 capsule protein antigen

18

What is the HIV window period?

The time between infection with the virus, seroconversion, and a reliable test result