HIV drugs

Question 1

nucleoside analog MOA and resistance

Answer 1

pro drugs
activated by host cell kinases, inhibits viral RT

RT point mutations wont except these drugs into chain

Question 2

Tx regimen usually inscludes

Answer 2

backbone- 2 NRTI’s

Base, one of the others

Question 3

tenofovir

Answer 3

only nucleotide analog

Question 4

excretion of NRTI

Answer 4

zidovudine and abacavir are hepatic rest are renal

Question 5

abacavir adverse reaction

Answer 5

severe hypersensitivity rxn

Question 6

Zidovudine s/e

Answer 6

anemia, neutropenia

Question 7

NNRTI MOA + resistance

Answer 7

bind to non-catalytic site, inhibit RT

point mut to RT

Question 8

Efavirenz DDI

Answer 8

induces CYP3A4 (decrrease methadone levels)

Question 9

ending of protease inhibitors

Answer 9

navir

Question 10

NRTI ending

Answer 10

ine except for abacavir

Question 11

ritonavir metabolism effect

Answer 11

potent p450 inhibitor, used in boosting

Question 12

NNRTI adverse effects

Answer 12

rash headache, hepatic dysfunction, GI

Question 13

prtotease inhibitor s/e

Answer 13

GI, fat redistribution, hyperlipidemia, pancreatitis, nephrolithiasis

Question 14

protease inhibitor moa + resistance

Answer 14

Noncleavable peptidomimetic agents that selectively target retroviral aspartyl proteases
Relatively high barrier to resistance

Question 15

Darunavir: side effects

Answer 15

rash can be severe (S-J Syndrome)

Question 16

Integrase inhibitor MOA, ending, resistance

Answer 16

Viral integrase involved in processing of DNA strands and catalyzing direct insertion of viral DNA into host cell DNA

tegra

No effect on human DNA polymerases α, β, or γ

Resistance
high barrier

Question 17

integrase inhibitor side effects

Answer 17

Myopathy, rhabdomyolysis, and skin reactions reported but rare

Question 18

Maraviroc

Answer 18

CCR5 tropic HIV blocker

Question 19

Enfuvurtide MOA, S/E

Answer 19

fusion inhibitor through gp 41

injection site inflammation