HIV - DRUGS AND AGENTS Flashcards
(76 cards)
1
Q
BIKTARVY COMPONENTS
A
INSTI - BICTEGRAVIR
NRTI - EMTRICITABINE
NRTI - TAF
2
Q
TRIUMEQ COMPONENTS
A
INSTI - DOLUTEGRAVIR
NRTI - ABACAVIR
NRTI - LAMIVUDINE
3
Q
DOVATO COMPONENTS
A
INSTI - DOLUTEGRAVIR
NRTI - LAMIVUDINE
4
Q
STRIBILD COMPONENTS
A
INSTI - ELVITEGRAVIR
BOOSTER - COBICISTAT
NRTI - EMTRICITABINE
NRTI - TDF
5
Q
GENVOYA COMPONENTS
A
INSTI - ELVITEGRAVIR
BOOSTER - COBICISTAT
NRTI - EMTRICITABINE
NRTI - TAF
6
Q
ATRIPLA COMPONENTS
A
NNRTI - EFAVIRENZ
NRTI - EMTRICITABINE
NRTI - TDF
7
Q
COMPLERA COMPONENTS
A
NNRTI - RILPIVIRINE
NRTI - EMTRICITABINE
NRTI - TDF
8
Q
ODEFSEY COMPONENTS
A
NNRTI - RILPIVIRINE
NRTI - EMTRICITABINE
NRTI - TAF
9
Q
EPZICOM COMPONENTS
A
NRTI - ABACAVIR
NRTI - LAMIVUDINE
10
Q
DESCOVY COMPONENTS
A
NRTI - EMTRICITABINE
NRTI - TAF
11
Q
TRUVADA COMPONENTS
A
NRTI - EMTRICITABINE
NRTI - TDF
12
Q
ABACAVIR SINGLE AGENT BRAND NAME
A
ZIAGEN
13
Q
EMTRICITABINE SINGLE AGENT BRAND NAME
A
EMTRIVA
14
Q
LAMIVUDINE SINGLE AGENT BRAND NAME
A
EPIVIR
15
Q
TDF SINGLE AGENT BRAND NAME
A
VIREAD
16
Q
TAF SINGLE AGENT BRAND NAME
A
NONE FOR HIV
VEMLIDY FOR HBV
17
Q
ZIDOVUDINE SINGLE AGENT BRAND NAME
A
RETROVIR
18
Q
BICTEGRAVIR SINGLE AGENT BRAND NAME
A
NONE, ONLY AVAILABLE AS COMBO IN BIKTARVY
19
Q
DOLUTEGRAVIR SINGLE AGENT BRAND NAME
A
TIVICAY
20
Q
ELVITEGRAVIR SINGLE AGENT BRAND NAME
A
NONE, ONLY IN COMBO IN GENVOYA AND STRIBLID
21
Q
RALTEGRAVIR SINGLE AGENT BRAND NAME
A
ISENTRESS
ISENTRESS HD
22
Q
EFAVIRENZ SINGLE AGENT BRAND NAME
A
SUSTIVA
23
Q
RILPIVIRINE SINGLE AGENT BRAND NAME
A
EDURANT
24
Q
ATAZANAVIR SINGLE AGENT BRAND NAME
A
REYATAZ
25
DARUNAVIR SINGLE AGENT BRAND NAME
PREZISTA
26
RITONAVIR SINGLE AGENT BRAND NAME
NORVIR
27
COBICISTAT SINGLE AGENT BRAND NAME
TYBOST
28
MARAVIROC MOA
CCR5 ANTAGONIST
| BLOCKS BINDING AND ENTERING (STAGE 1)
29
FOSTEMSEVIR MOA
ATTACHMENT INHIBITOR
| BINDS ENVELOPE PROTEINS, BLOCKING STAGE 1
30
IBALIZUMAB-UIYK MOA
POST ATTACHMENT INHIBITOR
| MAB THAT BINDS TO CD4 RECEPTOR - BLOCKS STAGE 1
31
ENFUVIRTIDE MOA
FUSION INHIBITOR
| PREVENTS FUSION TO CD4 (STAGE 2)
32
NRTI CLASS AGENTS
| WHICH ONES ARE NOT LONGER RECOMMENDED?
ZDS - LATTE
```
ZIDOVUDINE
DIDANOSINE (XX)
STAVUDINE (XX)
LAMIVUDINE
ABACAVIR
TDF
TAF
EMTRICITABINE
```
33
WHICH NRTIS REQUIRE RENAL DOSE ADJUSTMENT?
DOSE DECREASE FOR ALL NRTIS
34
WHICH NRTI IS GIVEN DURING LABOR AND DELIVERY TO PROTECT THE BABY?
ZIDOVUDINE
35
WARNING FOR ALL NRTIS
| THESE WARNINGS ARE ALSO BOXED WARNING FOR WHICH NRTI?
LACTIC ACIDOSIS
HEPATOMEGALY
(BOXED WARNING FOR Z D S)
36
COMMON SIDE EFFECTS FOR NRTIS
N, D, HEADACHE
| ↑ LFTS
37
HBV AND HIV CONINFECTION WARNING
SEVERE ACUTE HBV EXACERBATION CAN OCCUR IF EMTRICITABINE, LAMIVUDINE, OR TENOFOVIR PRODUCTS ARE DISCONTINUED
38
WHICH NRTI HAS INCREASED RISK OF MI
ABACAVIR
39
WHICH NRTI HAS RISK OF HYPERPIGMENTATION? WHERE DOES THIS HYPERPIGMENTATION OCCUR?
EMTRICITABINE
PLAMS OF HANDS
SOLES OF FEET
40
TDF VS TAF, WHICH HAS HIGHER RISK OF ADVERSE EFFECTS
TDF HAS HIGHER RISK OF
- RENAL IMPAIRMENT
- OSTEOPOROSIS (BONE LOSS)
41
RENAL IMPAIRMENT WITH TDF AND TAF
| WHAT CRCL SHOULD AVOID ONE OR THE OTHER?
DO NOT START TAF < 30
DO NOT START TDF < 50
STRILBID, DO NOT START < 70
DC STRILBID < 50
42
WHICH NRTI HAS RISK OF LIPID ABNORMALITIES?
TENOFOVIR PRODUCTS
| TAF HAS HIGHER RISK COMPARED TO TDF
43
WHICH NRTI HAS RISK OF HEMATOLOGIC TOXICITY?
ZIDOVUDINE
NEUTROPENIA
ANEMIA
(↑ MCV IS SIGN OF ADHERENCE)
44
WHICH NRTI HAS RISK OF MYOPATHY?
ZIDOVUDINE
45
INSTI CLASS AGENTS
```
BRED
BICTEGRAVIR
DOLUTEGRAVIR
ELVITEGRAVIR
RALTEGRAVIR
```
46
COMMON SIDE EFFECTS FOR INSTIS
HA, INSOMNIA,
DIARRHEA, WEIGHT GAIN
DEPRESSION AND SI IN PATIENTS WITH PRE-EXISTING PSYCH CONDITIONS
47
WHICH INSTI HAS THE LOWEST RISK OF DEPRESSION OR SI?
BICTEGRAVIR
48
WHICH INSTIS CAN INCREASE SCR WITH NO EFFECT ON GFR?
BICTEGRAVIR
| DOLUTEGRAVIR
49
WHICH INSTIS INCREASE CPK, AND RISK OF MYOPATHY AND RHABDO?
RALTEGRAVIR
| DOLUTEGRAVIR
50
WHICH INSTI HAS RISK OF PROTEINURIA?
ELVITEGRAVIR
51
WHICH INST HAS RISK OF HYPERSENSITIVITY REACTION?
DOLUTEGRAVIR
52
WHICH INSTI HAS RISK OF NEURAL TUBE DEFECTS IN WOMEN?
DOLUTEGRAVIR
| EVEN SO, IS STILL THE PREFERRED FOR PREGNANCY
53
INSTI DRUG INTERACTION? WHICH INSTI SHOULD PROBABLY AVOID THIS INTERACTION ENTIRELY?
WITH POLYVALENT CATIONS
- TAKE INSTIS 2 HOURS BEFORE OR 6 HOURS AFTER
- THIS SEPARATION DOES NOT WORK WITH RALTEGRAVIR AND SHOULD BE AVOIDED IF POSSIBLE
54
NNRTI CLASS AGENTS
| WHICH ARE NO LONGER RECOMMENDED
RED
RILPIVIRINE
EFAVIRENZ
DELVIRDINE (XX)
55
BETWEEN EFAVIRENZ AND RILPIVIRINE, WHICH SHOULD BE WITH FOOD VS EMPTY STOMACH?
RILPIVIRINE TAKE WITH FOOD TO CREATE ACIDIC ENVIRONMENT
| EFAVIRENZ ON EMPTY STOMACH
56
WHY IS IT RECOMMENDED FOR ONE NNRTI TO BE TAKEN ON AN EMPTY STOMACH?
EFAVIRENZ
FOOD INCREASES BIOAVAILABILITY AND RISK FOR CNS SIDE EFFECTS
RECOMMENDED TO BE TAKEN ON EMPTY STOMACH AT NIGHT
57
KEY DRUG INTERACTION FOR RILPIVIRINE?
RILPIVIRINE NEEDS ACIDIC ENVIRONMENT FOR ABSORPTION
DO NOT USE PPIS
SEPARATE FROM H2RAS BY ≥12H BEFORE OR 4H AFTER RILPIVIRINE
SEPARATE FROM ANTACID BY ≥2H BEFORE OR 4H AFTER RILPIVIRINE
58
ALL NNRTI HAVE THIS WARNING
HEPATOTOXICITY
| RASH - SJS/TENS
59
COMMON SIDE EFFECT WITH NNRTI
PSYCHIATRIC SIDE EFFECT
| DEPRESSION, SI
60
EFAVIRENZ SPECIFIC SIDE EFFECTS?
```
CNS EFFECTS (ABNORMAL DREAMS, IMPAIRED CONCENTRATION, CONFUSION) WHICH RESOLVE IN 2-4 WEEKS
↑ TC AND TG
```
61
RILPIVIRINE SPECIFIC SIDE EFFECTS?
↑ SCR WITH NO EFFECT ON GFR
62
WHICH NNRTI SHOULD BE AVOIDED IF VIRAL LOAD IS TOO HIGH OR CD4 TOO LOW? WHY?
RILPIVIRINE - HIGH FAILURE RATE
| AVOID IF VIRAL LOAD >100,000 AND/OR CD4 <200
63
PROTEASE INHIBITOR CLASS AGENTS
ATAZANAVIR
| DARUNAVIR
64
ALL PROTEASE INHIBITORS ARE RECOMMENDED TO BE TAKEN WITH A...
BOOSTER
| RITONAVIR OR COBICISTAT
65
PROTEASE INHIBITORS SHOULD BE TAKEN WITH FOOD?
YES, TO AVOID GI UPSET
| ATAZANAVIR ALSO NEEDS THE ACIDIC ENVIRONMENT
66
PROTEASE INHIBITORS RENAL DOSE ADJUSTMENTS?
NONE NEEDED
67
3 BIG WARNINGS WITH PROTEASE INHIBITORS
- METABOLIC ABNORMALITIES (BG, LIPIDS, BODY FAT) RESULTING IN INCREASED CVD RISK
- HEPATIC DYSFUNCTION (LFTS, HEPATITIS)
- HYPERSENSITIVITY (RASH, SJS/TENS)
68
WHICH PI IS KNOWN AS "BANANAVIR"? WHY?
ATAZANAVIR
ASSOCIATED WITH HYPERBILIRUBINEMIA (JAUNDICE AND YELLOWING OF SKIN AND EYES)
REVERSIBLE
69
WHICH PI REQUIRES AN ACIDIC ENVIRONMENT?
```
ATAZANAVIR
AVOID PPIS WHEN UNBOOSTED
SEPARATE FROM PPI BY 12H IF BOOSTED
AVOID H2RAS OR TAKE ATAZANAVIR 2H BEFORE OR 10H AFTER
TAKE ATAZANAVIR 2H OR 1H AFTER ANTACIDS
```
70
WHICH PI SHOULD EB AVOIDED IN SULFA ALLERGY?
DARUNAVIR
71
PK BOOSTERS AGENTS
RITONAVIR
| COBICISTAT
72
HOW SHOULD RITONAVIR BE TAKEN?
WITH FOOD
73
RITONAVIR ORAL SOLUTION?
CONTAINS 42% ALCOHOL
| CAN TRIGGER DISULFIRAM REACTION WITH METRONIDAZOLE
74
HOW SHOULD COBICISTAT BE TAKEN?
WITH THE BOOSTED DRUG AND WITH FOOD
75
BOOSTERS INHIBIT WHICH ENZYME THAT MAKE THEM BENEFICIAL?
CYP3A4
| ALSO INHIBIT CYP2D6, PGP, AND OTHER TRANSPORTERS
76
WHICH DRUGS ARE CONTRAINDICATED WITH RITONAVIR AND COBICISTAT?
```
LOVASTATIN AND SIMVASTATIN
COLCHICINE
AZOLE ANTIFUNGALS
CV DRUGS
PDE5 INHIBITORS FOR PULMONARY HTN
TKI
CYP3A4 INDUCERS
ANY NARROW THERAPEUTIC INDEX DRUG
```
