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Molecular Immunology > HIV Vaccine > Flashcards

Flashcards in HIV Vaccine Deck (21):
1

Why is the cell an ideal environment for a virus?

The cell has ample energy and proteins.

2

When in evolution did the definition of self and non self become crucial?

With the evolution of the cell membrane.

3

What crucial events in the origin of AIDS happened in 1980?

There was an increase of unusual and opportunistic infections as well as rare cancers.

4

What rare disease was a hallmark of an aids pandemic?

Cryptococcus fungi infection (brain fungi).

5

What rare cancer was a hallmark of an aids pandemic?

Kaposi sarcoma.

6

What can also be a hallmark of an AIDS pandemic in addition to rare disease?

Increase in other diseases caused by unprotective sex on the rise, showing that safe sex practices are not being followed.

7

Who reported the increase in rare diseases at the start of the AIDS pandemic?

Ken Horne

8

Cryptococcus fungi was shown to rise at the start of the AIDS pandemic. What social group is this disease often see in?

Immunosupressed patients.

9

What happened in 1981 in regards to the AIDS pandemic?

The first mention of the affliction affecting gay men in NYC. This was dismissed by the City Health Officials.

10

What disease had 5 reported cases in LA at the time of the AIDS pandemic?

Pneumocystis pneumonia.

11

What happened in 1983 in regards to the AIDS pandemic?

Montagnier and Sineussi isolated a reterovirus from the lymph system of a patient.

12

What could the reterovirus isolated by Montagnier and Sineussi do?

Activate and kill T lymphocytes.

13

What two social groups was the same reterovirus, previously isolated from Montagnier and Sineussi , also isolated from?

Further gay paitents and haemophiliacs.

Haemophiliacs had the reterovirus as often intravenous drug users.

14

Who did the health secretary Margaret Heckler announce discovered the cause of AIDS in 1984?

Robert Gallo.

15

What type of reterovirus was the aids reterovirus known as?

A lentivirus- reterovirus with a long incubation period.

16

What does the AIDS reterovirus integrate into the genome as?

Provirus.

17

In 1986 how many people were infected from AIDS?

1 million.

18

Why could a drug be maid against AIDS?

It was known how a RT replicated.

19

What was developed in 1987?

AZT.

20

What was developed in 1992?

Combination therapies.

21

What was developed in 1995 which meant the death rate of HIV dramatically fell?

Protease inhibitors.