Monk 1 Flashcards
1
Q
What activators of inflammation are produced in large amounts during complement activation?
A
C3a C5a.
2
Q
What can C3a and C5a bind to?
A
GPCRs on neutrophils and monocytes
3
Q
What can rapidly inactivate C3a and C5a?
A
Carboxypeptidase
4
Q
Name two situations when C3a and C5a are elevated?
A
- Sepsis
2. Inflammatory conditions such as RA.
5
Q
What do most cells in the body have receptors for?
A
C3a and C5a.
6
Q
C3a and C5a have receptors on most cells of the body. What are C3a and C5a hence classed as?
A
Chemoattractants.
7
Q
Why do C3a and C5a have to be rapidly degraded?
A
They are potent.
8
Q
When Mast cells can be over activated what can be caused?
A
Anaphylactic shock.
9
Q
What is a definition for asthma?
A
’ Complex inflammatory disease in the bronchi’.
