HIVSH1 Flashcards

1
Q

Fusion

A

HIV Fusing with cell membrane of CD4. Release cytoplasm into the CD4 cell = entry = binding and fusion
Once single stranded HIV RNA inside the cell the next step is reverse transcription ( transcription: double stranded DNA transcribed into single stranded messenger RNA). Reverse transcription is the opposite

Single stranded HIV RNA turning itself into a double stranded HIV DNA. Done by HIV enzyme called reverse transcriptase.
Once you have HIV DNA, whole reason for this whole reverse transcription was for HIV virus to get double stranded DNA. This double stranded HIV DNA can integrate itself with the host cell DNA ( which also is double stranded DNA ). = integration. Done by enzyme integrase.

Now when host cell dna replicates, it’ll automatically replicate HIV DNA with itself at the same time. Thats how HIV virus uses CD 4 to replaicate its genetics material. Transcription and translation. = messenger RNA gets encoded to amino acid chain. Long chain. Needs to broken down to functional units.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

LAND FIRST pneumonic

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Viral enzymes gets made for HIV RNA virus to bud off host cell.

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

First set of medications are gonna be entry inhibitors.
Entry: binding and fusion

A

Binding inhibitors: ibalizumab

Fusion inhibitors: enfuvirtide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

NRTI side effects all have SE’s that are common to the whole class

A

T

Lactic acidosis
Headache

And #3) fatty liver : hepatic statosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

NNRTIs common SE:

A

Rash

Hepatotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Integrase inhibitors

A

RBED

GI
Nausea
HA
Fatigue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Protease inhbitors

A

LAND FIRST
All end with navir

All can cause hyperglycemia, hyperlipdemia and Lipodystophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

First step inside the cell is

A

Transcription

NRTis and NNRTIs are first step inside the cell blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Last step before viral genetic material and viral enzymes bud off are

A

Protease inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Inducers pneumonic

A

SRCOP

S-st John’s wort / Sustiva ( efavirenz )
R- rifampin /
C- carbamazapine
O- Oxcarbamazapine
P- pheytoin and phenobarbital

How well did you know this?
1
Not at all
2
3
4
5
Perfectly