Hodgkin and Non-Hodgkin Lymphoma Flashcards Preview

B&L Unit 2 > Hodgkin and Non-Hodgkin Lymphoma > Flashcards

Flashcards in Hodgkin and Non-Hodgkin Lymphoma Deck (18)
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1
Q

Describe the basic anatomy of a normal lymph node

A

Consists of…

1) Capsule: on outside, usually thin and fibrous
2) Cortex: lymphoid follicles and paracortex (T-cells)
3) Medulla: medullary cords (lymphocytes, plasma cells, macros, DCs)
4) Sinuses

2
Q

Describe the common abnormal lymph node patterns seen in lymphomas

A

Just a lack of normal appearance in lymph nodes indicates pathology

You see remarkable changes in germinal centers, follicles, and other lymph node features in lymphomas

3
Q

Define lymphadenopathy

A

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4
Q

What are the common disease categories associated with lymphadenopathies?

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5
Q

What are the basic principles for the WHO classification of lymphomas?

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6
Q

Describe common non-Hodgkin lymphoma based on cytology, pattern of growth, immunophenotype, and genetic alteration

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7
Q

What does indolent mean in relation to lymphoma?

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8
Q

What does aggressive mean in relation to lymphoma?

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9
Q

What does highly aggressive mean in relation to lymphoma?

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10
Q

What are some common types of indolent lymphomas?

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11
Q

What are some common types of aggressive lymphomas?

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12
Q

What are common types of lymphomas in adults? Describe them

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13
Q

What are common types of lymphomas in children? Describe them

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14
Q

Explain the importance of rearrangements involving the BCL2 genes in the pathogenesis of lymphoma

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15
Q

Explain the importance of rearrangements involving the BCL1 genes in the pathogenesis of lymphoma

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16
Q

Explain the importance of rearrangements involving the MYC genes in the pathogenesis of lymphoma

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17
Q

What are the major subtypes of classical Hodgkin lymphoma? Describe them

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18
Q

Describe the Reed-Sternberg cell in CHL

A

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