Hodgkin and Non-Hodgkin Lymphoma Flashcards
(18 cards)
Describe the basic anatomy of a normal lymph node
Consists of…
1) Capsule: on outside, usually thin and fibrous
2) Cortex: lymphoid follicles and paracortex (T-cells)
3) Medulla: medullary cords (lymphocytes, plasma cells, macros, DCs)
4) Sinuses
Describe the common abnormal lymph node patterns seen in lymphomas
Just a lack of normal appearance in lymph nodes indicates pathology
You see remarkable changes in germinal centers, follicles, and other lymph node features in lymphomas
Define lymphadenopathy
a
What are the common disease categories associated with lymphadenopathies?
a
What are the basic principles for the WHO classification of lymphomas?
a
Describe common non-Hodgkin lymphoma based on cytology, pattern of growth, immunophenotype, and genetic alteration
a
What does indolent mean in relation to lymphoma?
a
What does aggressive mean in relation to lymphoma?
a
What does highly aggressive mean in relation to lymphoma?
a
What are some common types of indolent lymphomas?
a
What are some common types of aggressive lymphomas?
a
What are common types of lymphomas in adults? Describe them
a
What are common types of lymphomas in children? Describe them
a
Explain the importance of rearrangements involving the BCL2 genes in the pathogenesis of lymphoma
a
Explain the importance of rearrangements involving the BCL1 genes in the pathogenesis of lymphoma
a
Explain the importance of rearrangements involving the MYC genes in the pathogenesis of lymphoma
a
What are the major subtypes of classical Hodgkin lymphoma? Describe them
a
Describe the Reed-Sternberg cell in CHL
a
