Describe the basic anatomy of a normal lymph node
Consists of…
1) Capsule: on outside, usually thin and fibrous
2) Cortex: lymphoid follicles and paracortex (T-cells)
3) Medulla: medullary cords (lymphocytes, plasma cells, macros, DCs)
4) Sinuses
Describe the common abnormal lymph node patterns seen in lymphomas
Just a lack of normal appearance in lymph nodes indicates pathology
You see remarkable changes in germinal centers, follicles, and other lymph node features in lymphomas
Define lymphadenopathy
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What are the common disease categories associated with lymphadenopathies?
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What are the basic principles for the WHO classification of lymphomas?
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Describe common non-Hodgkin lymphoma based on cytology, pattern of growth, immunophenotype, and genetic alteration
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What does indolent mean in relation to lymphoma?
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What does aggressive mean in relation to lymphoma?
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What does highly aggressive mean in relation to lymphoma?
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What are some common types of indolent lymphomas?
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What are some common types of aggressive lymphomas?
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What are common types of lymphomas in adults? Describe them
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What are common types of lymphomas in children? Describe them
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Explain the importance of rearrangements involving the BCL2 genes in the pathogenesis of lymphoma
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Explain the importance of rearrangements involving the BCL1 genes in the pathogenesis of lymphoma
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Explain the importance of rearrangements involving the MYC genes in the pathogenesis of lymphoma
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What are the major subtypes of classical Hodgkin lymphoma? Describe them
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Describe the Reed-Sternberg cell in CHL
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