Hodgkin's Lymphoma

Question 1

What is the cellular characteristic that defines Hodgkin’s Lymphoma?

Answer 1

The Reed-Sternberg Cell

Question 2

Reed-Sternberg cells secrete _______ which attract _________

Answer 2

Cytokines; inflammatory cells (neutrophils, lymphocytes, eosinophils, macrophages, etc.)

Question 3

What is the key difference in cellular composition between a NHL mass and a Hodgkin’s Lymphoma mass?

Answer 3

NHL mass: composed of neoplastic cells only

HL mass: composed of a little tumor cell (R-S cell) and mostly inflammatory cells

Question 4

Describe the nodal involvement and spread seen in HL

Answer 4

typically cervical or mediastinal masses/lymphadenopathy
spreads contiguously (linear)

Question 5

What are the characteristic CD markers of Reed Sternberg cells, as well as the hallmark shape?

Answer 5

B cells with CD15 and CD30 (but no CD20!)

binucleate, double owl’s eye (not CMV!)

Question 6

The prognosis of HL improves as what cell type increases proportionally?

Answer 6

Lymphocytes

Question 7

Describe the characteristics of the most common type of HL

Answer 7

Nodular sclerosing HL
fibrotic collagen bands divide the LN follicles
Lacunar cells: R-S cells sitting in ‘lakes’
women>men, young adults (hi lymphocytes)

Question 8

Describe the crappiest form of HL

Answer 8

Lymphocyte depleted HL (duh)

seen in old or HIV pts