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ENGR 1 > HodgkinLymphomas > Flashcards

HodgkinLymphomas Flashcards

1
Q

Types of mature lymphoid neoplasms

A
  1. Hodgkin lymphoma 
2. Non-Hodgkin lymphoma 
3. Plasma cell neoplasm
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2
Q

B Cell specific markers

A

CD19 
CD22 
CD20

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3
Q

T Cell specific markers

A

CD3 
CD7 
CD5

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4
Q

Germinal center B cell markers:

A

CD20 BCL6 CD10

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5
Q

Neoplastic follicle marker:

A

BCL1 
- activate genes for cell cycle progression


BCL2 
- suppress apoptosis

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6
Q

Types of Non-Hodgkin Lymphoma

A
  1. Burkitt lymphoma 
2. Follicular lymphoma 
3. Mantle cell lymphoma 
4. CLL/SLL
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7
Q

Types of Plasma cell neoplasm

A
  1. Monoclonal Gammaopathy of Undetermined Significance (MGUS) 

  2. Plasmacytoma 

  3. Plasma Cell myeloma (Multiple myeloma)
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8
Q

Non-Hogkin lymphoma

A

Malignancy derived from Mature B cells, T cells, NK cells

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9
Q

Translocation/Chromosomal abnormality of Burkitt lymphoma:

A

t(8;14)

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10
Q

Translocation/Chromosomal abnormality of Follicular lymphoma:

A

t(14;18)

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11
Q

Translocation/Chromosomal abnormality of Mantle cell lymphoma:

A

t(11;14)

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12
Q

Translocation/Chromosomal abnormality of CLL/SLL:

A

Del13q14

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13
Q

Cytogenetic marker of Burkitt lymphoma:

A

CD19 
CD20

MYC

GC: CD10, BCL6

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14
Q

Cytogenetic marker of Follicular lymphoma

A

CD19 
CD20

BCL2

GC:CD10, BCL6

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15
Q

Cytogenetic marker of Mantle cell lymphoma

A

CD19 
CD20

BCL1 (cyclin D1), 
CD5

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16
Q

Cytogenetic marker of CLL/SLL:

A

CD19
CD23

CD5

17
Q

Which Non-Hogkin lymphoma is associated with EBV?

A

Burkitts lymphoma

- Sporadic: 30%

- Endemic: 95%

- Immunodeficient: 24-40%

18
Q 
Non-Hodgkin Lymphoma grade: 
1. Burkitt lymphoma 

2. Follicular lymphoma 

3. Mantle cell lymphoma 

4. CLL/SLL
A
  1. Burkitt lymphoma - High (aggressive) 

  2. Follicular lymphoma - Low grade 

  3. Mantle cell lymphoma - Low grade (More aggressive than FL and CLL) 

  4. CLL/SLL: Low grade
19
Q

Histo findings of Burkitt Lymphoma

A

Starry sky pattern

basophilic cytoplasm 

round nuclei

20
Q

Histo findings of FL

A

No tingible body macrophages (homogenous tumor) 


Neoplastic follicles in lymph node cortex or medulla (not just cortex)

21
Q

Histo findings of Mantle cell lymphoma

A

larger than normal lymphocyte

22
Q

Histo findings of CLL/SLL:

A

lymphocytosis (in bm/lymph node) > 3 months

Prolymphocyte

Lymph node effacement 

proliferation center replace germinal center

23
Q

Which Non-hodgkin lymphoma is usually assymptomatic?

A

Mantle cell lymphoma 
CLL/SLL

24
Q

Which Non-hodgkin lymphoma displays a starry sky pattern?

A

Burkitt lymphoma

ENGR 1 (29 decks)

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