Homeostasis 1&2 Flashcards

(54 cards)

1
Q

Homeostasis

A

Property of a system in which a variable is actively regulated to remain very nearly constant

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2
Q

Tissues

A

Group of cells sharing same characteristics or specialisations

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3
Q

Organs

A

Collections of tissues, usually several types, synchronised to perform a function

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4
Q

Literal meaning of homeostasis

A

Homeo = similar stasis = condition

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5
Q

The 2 systems which co-ordinate and control all of the systems

A

Nervous and endocrine

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6
Q

Physiology

A

Study of how the body works normally - optimum conditions with body constantly monitoring internal state and responding to disruption

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7
Q

3 Common challenges to internal environment

A

Diet, exercise and temperature

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8
Q

These 3 factors of challenges to internal environment impact on what 3 things

A
  • Bodily fluid composition
  • Energy stores
  • Body temperature
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9
Q

At extremes does homeostasis become more or less effective?

A

Less

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10
Q

Describe the mechanism of negative feedback control

A
  • Magnitude of change in monitored variable
  • Sensed by receptor
  • Compared to reference level in integrating centre
  • Signal to effector to generate response
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11
Q

Is the magnitude of generated signal and response smaller than, proportional to or greater than the magnitude of difference from normal?

A

Proportional to

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12
Q

Can negative feedback prevent the change

A

No can only correct after the system has been displaced

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13
Q

Negative feedback: self amplifying or self limiting?

A

Self limiting

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14
Q

Homeotherm

A

Maintain constant core temperature over a wide range of external temperatures

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15
Q

Feed forward have what additional feature?

A

Additional receptors to detect and anticipate change earlier eg temperature receptors in skin

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16
Q

Positive feedback: self amplifying or self limiting?

A

Self amplifying

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17
Q

Is positive feedback common in normal health or pathology?

A

Pathology eg diabetes mellitus and cancer

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18
Q

Give 2 examples of positive feedback in normal health

A

Nerve action potential and ovulation and sexual behaviour

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19
Q

Hyperglycaemia

A

Associated with diabetes and includes neural dysfunction, blindness, kidney damage and electrolyte disturbances

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20
Q

Homeostatic mechanisms represented by reflexes - name the 2 types these reflexes can be

A

Neural and/or hormonal

Simple or complex

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21
Q

Give 4 examples that homeostasis can control

A
  • O2 and CO2 levels
  • Water and ion balance
  • Blood pressure and blood volume
  • Nutrient levels
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22
Q

How much in percentage does water make up of the human body?

23
Q

Describe how the output and input mechanism is controlled in humans

A
Input = thirst mechanism
output = urinary losses
24
Q

Extra cellular fluid includes

A

Plasma and interstitial fluid

25
ECF found in special areas eg CSF and joint fluid
Transcellular fluid
26
Is the ICF or ECF very important to be maintained in a state compatible with survival?
ECF
27
Average Man
21 years old, healthy, 70Kg
28
Difference between plasma and ISF
Plasma proteins in plasma
29
What is the volume of plasma
3L
30
What is the volume of ISF
11L
31
What is the total volume of ECF
14L
32
Intracellular fluid = volume and what is it high in K+ or Na+
28L and high in potassium and also magnesium
33
When you administer a drug that freely crosses cell membranes (non polar) what is the compartment distribution?
1/3 ECF 2/3 ICF
34
Proportion of water in body varies with
Age, sex and BMI
35
Water content of muscle
70%
36
Water content of fat
10%
37
Higher BMI = more/less wet?
Less wet
38
Will lipid/water soluble drugs be excreted faster or slower in people with a higher BMI and why
Slower as the drugs will easier dissolve in fat
39
Describe the trend in males and females with age and body water content
From puberty onwards women show a lower body water content but both sexes decrease with age due to a loss of muscle mass
40
Dilution principle equation
volume = amount of tracer ( amount injected minus any excreted or metabolised)/ concentration of tracer in sample
41
Criteria for test substance/tracer
- Non toxic - Not metabolised or excreted - Even distribution in compartment measured - No effect on water distribution - Easy to measure
42
What 3 compartments can be measured directly?
Plasma, ECF and TBW
43
Plasma volume measurement
Use dyes/radioactive labels to attach to the proteins eg evans blue or I125 albumin
44
ECF volume
Inulin, sucrose, mannitol or Na/Cl ions
45
TBW volume
Radioactive water = D2O
46
ISF volume
ECF-PV
47
ICF volume
TBW-ECF
48
perturbation
deviation of system from normal
49
Do you want potassium in or out of cells?
In
50
Hyper
Greater than normal
51
Hypo
Less than normal
52
Aemia/emia
Relating to blood
53
Uria
In the urine
54
Glyc
Relating to glucose